Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1220 for “"collagen"”.
-
Nerve regeneration induced by collagen-GAG matrix in collagen
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1994.
-
Optimizing collagen fibers for use in a collagen engine.
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1969.
-
Type I collagen proteostasis
The folding, quality control, and secretion of collagen presents a significant challenge to collagen-producing cells. Each monomeric polypeptide must undergo extensive post-translational modifications, folding and assembly of the C-terminal propeptide globular domain, and isomerization of hundreds …
-
Stretching Collagen: Using Fluorophores in Collagen Mimetic Peptides as a Proposed Enantiomeric Sorting Technique
… universal, and some of them can be quite costly. Collagen mimetic peptides are naturally chiral and can exhibit reversible trimerization, making them attractive platforms for development of adjunct therapies. This research aims to create two fluorescent naphthalimide isomers to be embedded within …
-
Genipin-crosslinked electrospun collagen nanofibers
… and pore interconnectivity. In this research collagen type I nanofibers were fabricated using electrospinning. Collagen nanofibers were unstable in aqueous environments, and thus crosslinking was required. Glutaraldehyde, which is cytotoxic to cells, is currently the chemical crosslinking …
-
Design of Collagen-Mimetic Peptides
<p>Collagen is the major component of the extracellular matrix and is involved in a wide range of cellular functions during tissue development and action. At the core of the diverse functions of this versatile protein is its remarkable ability to form supramolecular structures through self-assembly …
-
The role of type I collagen heterotrimers and homotrimers in mechanical strength and collagen cleavage
Collagen is a crucial structural protein, formed through a hierarchical assembly of molecules, arranged in collagen fibrils, which constitutes the basis for larger-scale fibers. Normal type I collagen is a heterotrimer triple-helical molecule consisting of two alpha-1 chains and one alpha-2 chain. …
-
Collagen gene expression in human cancer
Type I collagen is the predominant collagen within the stroma and plays an important role in the processes of tumour cell invasion and metastasis during which the collagens within the stroma is degraded. Total RNA was extracted from different stages of breast cancer and adjacent normal tissue for …
-
GAG inhibition of collagen-platelet interaction
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1977
-
Spinal cord regression via collagen entubulation
(cont.) days) post-implantation. Histological and immunohistochemical analyses showed severe fibrous and glial scar formation in Groups I and III, less fibrous scarring in Group II and very little scar manifesting in Groups IV and V. A quantitative analysis of myelinated axons in the center of the …
-
Understanding collagen-l folding and misfolding
Chapter One: Introduction to Type I Collagen and Osteogenesis Imperfecta Collagen-I is the primary proteinaceous component of skin, bone, and tendon. Disruptions in collagen-I homeostasis, typically due to non-synonymous mutations in collagen-- encoding genes, cause a variety of severe incurable …
-
Viscoelastic characterization of collagen-GAG scaffolds
… study was performed to determine whether or not collagen-GAG scaffolds exhibit linear viscoelastic behavior. Tension tests were performed on dry and hydrated engineered collagen-GAG scaffolds in order to develop a stress-strain curve. Strains that fell in the linear elastic region of these curves …
-
Biomechanical properties of engineered collagen scaffolds
… the effect of crosslinking on the stiffness of collagen scaffolds. Engineered non-crosslinked and dehydrothermally crosslinked chondroitin-6-sulfate collagen scaffolds were hydrated and loaded in tension, and their mechanical properties were compared. It was found that non-crosslinked scaffolds …
-
The C-Propeptide in Collagen Proteostasis
Collagen folding is initiated at the C-terminal propeptide (C-Pro) domain, a globular domain wholly distinct from the collagen’s characteristic triple helix. The C-Pro domain is responsible for assembling three collagen strands into the correct orientation and stoichiometry and nucleating folding …
-
The mechanics of cell-seeded collagen hydrogels
… permeability and stiffness, of HepG2 cell-seeded collagen hydrogels. Confined compression testing in conjunction with biphasic theory modelling was utilised to provide measures of these mechanical parameters of interest. Different cell seeding densities and culture durations were tested to observe …
-
Aligned Fibrillar Collagen Matrices for Tissue Engineering
… cell behaviour for tissue regeneration. Aligned collagen fibrils were deposited on planar substrates from collagen solutions streaming through a microfluidic channel system. Collagen solution concentration, degree of gelation, shear rate and pre-coating of the substrate were demonstrated to …
-
Reconstituted collagen fibres for tissue engineering applications
In vitro, under appropriate conditions collagen molecules spontaneously form fibrils (fibrillogenesis) with the characteristic D-periodic banding similar to native fibrils. Recently, reconstituted collagen fibres have been of interest. Due to their unique advantageous properties, such as high …
-
Collagen Anchoring Agonist Antibodies for Cancer Immunotherapy
… restricted activity. To that end, we developed collagen anchored agonist antibodies, an approach we have previously validated with collagen anchored cytokines. When injected directly into the tumor, these collagen anchoring therapies are preferentially retained in the tumor microenvironment …
-
Collagen-mimetic peptides for diagnosis and analysis
Collagen, the most abundant protein in the human body, is an essential scaffold for tissue development, regulation, and homeostasis. As a major structural component of the extracellular matrix, collagen is not static. Rather, it is highly diverse and dynamic, actively participating in tissue …
Page 1 of 61