Toxicity of aliphatic amines on the embryos of zebrafish Danio rerio - experimental studies and QSAR

The toxicity of 36 aliphatic amines on the embryos of the zebrafish Danio rerio were investigated. The DarT (Danio rerio Toxicity assay) was used to determine the lethal concentrations within a 48 h static acute toxicity test. A QSAR (Quantitative Structure-Activity Relationship) was performed using the LC50 values and molecular descriptors such as lipophilicity, maximum positive charge on hydrogen atom and the effective diameter of the molecule. In general, the toxicity of primary and secondary amines could be described by the lipophilicity as descriptor. The toxicity of the tertiary amines tested could be only described by a bilinear regression model. Further, regression models for other aquatic species such as the fathead minnow Pimephales promelas, Daphnia magna and Tetrahymena pyriformis showed that the toxicity of each species is a good predictor for each other.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Technische Universität Dresden

Year

2002

Author dc:creator

• Brust, Kristin

Contributors dc:contributor

• Nagel, Roland
• Müller, Martin
• Worch, Eckhard

• Danio rerio
• QSAR
• Toxizität
• aliphatische Amine
• aliphatic amines
• toxicity