Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties

An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

Queen's University Belfast

Year dc:date.issued

2021

Author dc:creator

• Moffett-Culkin, Alice

Advisors dc:contributor.advisor

• Andrews, Gavin
• Li, Shu

• Mechanochemistry
• hot-melt extrusion
• eutectic
• multi-component pharmaceutical materials
• therapeutic deep eutectic
• salt
• reactive extrusion
• multivariate analysis

Language dc:language

eng

Identifier

oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b

OAI identifier oai:identifier

oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b