{"id":{"repo_id":"qu-belfast","oai_identifier":"oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b"},"canonical_url":"https://search.dev.ndltd.org/etd/qu-belfast/oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b","repository":{"repo_id":"qu-belfast","name":"Queen's University Belfast","base_url":"https://pureadmin.qub.ac.uk/ws/oai"},"display":{"title":"Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties","abstract":"An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.","abstract_html":"An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.&lt;br/&gt;&lt;br/&gt;&lt;i&gt;Thesis embargoed until 31 December 2026&lt;/i&gt;.","abstract_has_math":false,"creators":["Moffett-Culkin, Alice"],"institution":"Queen's University Belfast","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Andrews, Gavin","Li, Shu"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-12","date_published":"2021-12","updated_at":"2026-07-24T03:55:58Z","subjects":["Mechanochemistry","hot-melt extrusion","eutectic","multi-component pharmaceutical materials","therapeutic deep eutectic","salt","reactive extrusion","multivariate analysis"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b"],"render_values":[{"text":"oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.qub.ac.uk/en/studentTheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Andrews, Gavin","Li, Shu"]},{"key":"dc:contributor.sponsor","label":"Sponsor","values":["Northern Ireland Department for the Economy"]},{"key":"dc:creator","label":"Author","values":["Moffett-Culkin, Alice"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-12"]},{"key":"dc:date.issued","label":"Date","values":["2021-12"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Pharmacy"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Queen's University Belfast"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.qub.ac.uk/en/studentTheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mechanochemistry","hot-melt extrusion","eutectic","multi-component pharmaceutical materials","therapeutic deep eutectic","salt","reactive extrusion","multivariate analysis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights.embargodate","label":"Dc Rights Embargodate","values":["2026-12-31"]},{"key":"dc:rights.embargoreason","label":"Dc Rights Embargoreason","values":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b","https://pure.qub.ac.uk/en/studentTheses/b43aed7d-63fa-4310-a5b6-30e072a87e6b"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.<br/><br/><i>Thesis embargoed until 31 December 2026</i>."]},{"key":"dc:title","label":"Title","values":["Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties"]}]}],"canonical_facts":{"dc:contributor.advisor":["Andrews, Gavin","Li, Shu"],"dc:contributor.sponsor":["Northern Ireland Department for the Economy"],"dc:creator":["Moffett-Culkin, Alice"],"dc:date":["2021-12"],"dc:date.issued":["2021-12"],"dc:description.abstract":["An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. 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