Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma

The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.<br/><i><br/><br/></i>

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

Queen's University Belfast

Year dc:date.issued

2021

Author dc:creator

• Douglas, Rosalie

Advisors dc:contributor.advisor

• Turkington, Richard
• Kennedy, Richard

Language dc:language

eng

Identifier

oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc

OAI identifier oai:identifier

oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc