{"id":{"repo_id":"qu-belfast","oai_identifier":"oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc"},"canonical_url":"https://search.dev.ndltd.org/etd/qu-belfast/oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc","repository":{"repo_id":"qu-belfast","name":"Queen's University Belfast","base_url":"https://pureadmin.qub.ac.uk/ws/oai"},"display":{"title":"Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma","abstract":"The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.<br/><i><br/><br/></i>","abstract_html":"The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.&lt;br/&gt;&lt;i&gt;&lt;br/&gt;&lt;br/&gt;&lt;/i&gt;","abstract_has_math":false,"creators":["Douglas, Rosalie"],"institution":"Queen's University Belfast","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Turkington, Richard","Kennedy, Richard"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-7","date_published":"2021-7","updated_at":"2026-07-24T03:55:58Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc"],"render_values":[{"text":"oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.qub.ac.uk/en/studentTheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Turkington, Richard","Kennedy, Richard"]},{"key":"dc:creator","label":"Author","values":["Douglas, Rosalie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-7"]},{"key":"dc:date.issued","label":"Date","values":["2021-7"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Medicine, Dentistry and Biomedical Sciences"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Queen's University Belfast"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.qub.ac.uk/en/studentTheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights.embargodate","label":"Dc Rights Embargodate","values":["2023-07-31"]},{"key":"dc:rights.embargoreason","label":"Dc Rights Embargoreason","values":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc","https://pure.qub.ac.uk/en/studentTheses/9d23c4ab-bf2c-477a-b7d7-00a50299fdfc"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://pure.qub.ac.uk/files/243216193/Identification_of_targetable_mediators_of_resistance_to_chemotherapy_in_oesophageal_adenocarcinoma.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.<br/><i><br/><br/></i>"]},{"key":"dc:title","label":"Title","values":["Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma"]}]}],"canonical_facts":{"dc:contributor.advisor":["Turkington, Richard","Kennedy, Richard"],"dc:creator":["Douglas, Rosalie"],"dc:date":["2021-7"],"dc:date.issued":["2021-7"],"dc:description.abstract":["The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. 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