MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS

Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical reactions at their respective scales. The perspective taken in this dissertation is that of understanding B cells at the intracellular scale and the signaling molecules responsible for its responses.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Mathematics

Year

2015

Author dc:creator

• McGee, Reginald

Contributors dc:contributor

• Gregery T Buzzard
• Ann E Rundell
• Robert L Geahlen
• Zhilan Feng

• B cell signaling
• Computational Modeling
• Convergence Result
• Experimental Design
• Mutant
• Syk

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1312

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2528