{"id":{"repo_id":"purdue-thes","oai_identifier":"oai:docs.lib.purdue.edu:open_access_dissertations-2528"},"canonical_url":"https://search.dev.ndltd.org/etd/purdue-thes/oai:docs.lib.purdue.edu:open_access_dissertations-2528","repository":{"repo_id":"purdue-thes","name":"Purdue University","base_url":"https://docs.lib.purdue.edu/do/oai/"},"display":{"title":"MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS","abstract":"Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical reactions at their respective scales. The perspective taken in this dissertation is that of understanding B cells at the intracellular scale and the signaling molecules responsible for its responses.","abstract_html":"Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical reactions at their respective scales. The perspective taken in this dissertation is that of understanding B cells at the intracellular scale and the signaling molecules responsible for its responses.","abstract_has_math":false,"creators":["McGee, Reginald"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Mathematics","degree_department":null,"school":null,"contributors":["Gregery T Buzzard","Ann E Rundell","Robert L Geahlen","Zhilan Feng"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-01-01T08:00:00Z","date_published":"2015-01-01T08:00:00Z","updated_at":"2026-07-24T03:54:31Z","subjects":["B cell signaling","Computational Modeling","Convergence Result","Experimental Design","Mutant","Syk"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://docs.lib.purdue.edu/open_access_dissertations/1312","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gregery T Buzzard","Ann E Rundell","Robert L Geahlen","Zhilan Feng"]},{"key":"dc:creator","label":"Author","values":["McGee, Reginald"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Mathematics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["B cell signaling","Computational Modeling","Convergence Result","Experimental Design","Mutant","Syk"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://docs.lib.purdue.edu/open_access_dissertations/1312"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical reactions at their respective scales. The perspective taken in this dissertation is that of understanding B cells at the intracellular scale and the signaling molecules responsible for its responses."]},{"key":"dc:title","label":"Title","values":["MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS"]}]}],"canonical_facts":{"dc:contributor":["Gregery T Buzzard","Ann E Rundell","Robert L Geahlen","Zhilan Feng"],"dc:creator":["McGee, Reginald"],"dc:description.abstract":["Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical reactions at their respective scales. The perspective taken in this dissertation is that of understanding B cells at the intracellular scale and the signaling molecules responsible for its responses."],"dc:identifier":["https://docs.lib.purdue.edu/open_access_dissertations/1312"],"dc:subject":["B cell signaling","Computational Modeling","Convergence Result","Experimental Design","Mutant","Syk"],"dc:title":["MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS"],"thesis:degree_discipline":["Mathematics"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:54:31Z"}