UNDERSTANDING AND EVALUATING CRYSTAL POLYMORPHISM BY SECOND HARMONIC GENERATION MICROSCOPY

The crystalline form of a solid can profoundly affect its physical and chemical properties, with both potentially stable and metastable crystal polymorphs are accessible during crystal formation. Conventional methods limit the detection of rare nucleation and rapid phase transitioning events due to their lack of selectivity and sensitivity. Inkjet printing of a solution confines the nucleation event in a few micrometer volumes within the droplet, and furthermore rapid desolvation favors the kinetic factor to trap the rare metastable polymorphs. Second harmonic generation microscopy (SHG) possesses enough sensitivity to detect sub-micrometer size chiral crystals selectively and has the potential for use in crystal nucleation studies.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Year

2016

Author dc:creator

• Chowdhury, Azhad Chowdhury

Contributors dc:contributor

• Garth J Simpson
• Mary J Wirth
• Chittaranjan Das
• Lynne S Taylor

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1210

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2426