Chain-end functionalization and modification of polymers using modular chemical reactions

Taking advantage of ATRP and using functionalized initiators, different functionalities were introduced in both α and ω chain-ends of synthetic polymers. These functionalized polymers could then go through modular synthetic pathways such as click cycloaddition (copper-catalyzed or copper-free) or amidation to couple synthetic polymers to other synthetic polymers, biomolecules or silica monoliths. Using this general strategy and designing these co/polymers so that they are thermoresponsive, yet bioinert and biocompatible with adjustable cloud point values (as it is the case in the present thesis), the whole generated system becomes "smart" and potentially applicable in different branches. The applications which were considered in the present thesis were in polymer post-functionalization (in situ functionalization of micellar aggregates with low and high molecular weight molecules), hydrophilic/hydrophobic tuning, chromatography and bioconjugation (enzyme thermoprecipitation and recovery, improvement of enzyme activity). Different α-functionalized co/polymers containing cholesterol moiety, aldehyde, t-Boc protected amine, TMS-protected alkyne and NHS-activated ester were designed and synthesized in this work.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Universität Potsdam

Year

2012

Author dc:creator

• Zarafshani, Zoya

Contributors dc:contributor

• Laschewsky, André

• Atom Transfer Radical Polymerization
• Klick-Chemie
• Biokonjugation
• Funktionalisierung
• Modifizierung von Polymeren
• ATRP
• Click chemistry
• Bioconjugation
• Functionalization
• Polymer Modification

Statement dc:rights

• Keine öffentliche Lizenz: Unter Urheberrechtsschutz

Repository record source_url

https://publishup.uni-potsdam.de/frontdoor/index/index/docId/5808

OAI identifier oai:identifier

oai:kobv.de-opus4-uni-potsdam:5808