Ptychography for Nonlinear Optical Microscopy

In this thesis I will introduce a novel nonlinear optical microscopy method to address some of the shortcomings in the current nonlinear optical microscopy literature and offer a supplement to traditional fluorescent microscopy for label free optical biomedical imaging. In order to demonstrate this method I describe a method for the generation of a numerical sample of collagen fibrils, produce a set of numerical diffraction measurements. I introduce a novel Ptychography model for the simultaneous reconstruction of the components of the nonlinear optical susceptibility tensor and demonstrate the results of this model using numerically generated measurements from a numerical collagen sample. I additionally use the recovered information from Ptychography to retrieve new information about the structure of a sample.

Grantor dc:publisher

Université d'Ottawa / University of Ottawa

Year dc:date

2021

Author dc:creator

• Norris, Evan

Contributors dc:contributor

• Ramunno, Lora

• Nonlinear Optical Imaging
• Ptychography

Language dc:language

en

Identifier

http://dx.doi.org/10.20381/ruor-26868

OAI identifier oai:identifier

oai:ruor.uottawa.ca:10393/42648