The Effect of Exercise-induced Myokines on Placental Health and Function

Background: Exercise in pregnancy is associated with optimized fetal growth; however, the implicated mechanisms remain unknown. We hypothesize that exercise-induced myokines may be acting on the placenta to optimize fetal growth across gestation. Methodology: 1) Circulating profiles of 11 myokines were analyzed in 2nd trimester plasma of women characterized as active (N=14) or non-active (N=16) during pregnancy. 2) First trimester human placental explants (N=5) were treated with SPARC in a dose-dependent manner (0-150ng/ml). Metrics of placental health/function, including GLUT-4 expression/regulation, were assessed. Results: 1) Active women demonstrated an elevation in circulating SPARC compared to non-active women (86±19pg/ml vs. 52±18pg/ml, p=0.0001). 2) Explants treated with SPARC at 100ng/ml demonstrated improved invasion, with improved maximum outgrowth distance (N=3; p=0.0219). Conclusion: SPARC is a myokine that is elevated in the circulation of active pregnant women and is associated with improved placental invasion, suggesting a possible role of SPARC in placentation.

Grantor dc:publisher

Université d'Ottawa / University of Ottawa

Year dc:date

2017

Author dc:creator

• Dubé, Chantal

Contributors dc:contributor

• Bainbridge-Whiteside, Shannon
• Adamo, Kristi Bree

• placenta
• exercise
• pregnancy
• skeletal muscle
• myokines

Language dc:language

en

Identifier

http://dx.doi.org/10.20381/ruor-21005

OAI identifier oai:identifier

oai:ruor.uottawa.ca:10393/36725