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Showing 1 to 20 of 53 for “"SPARC"”.
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Integrins and SPARC : potential implications for cardiac remodeling
… Expression des matrizellulären Proteins SPARC, unterblieb nach AB in den Integrin Beta 1–defizienten Tieren. Interessanterweise konnte auch eine transiente Erhöhung der SPARC mRNA während der Umbauprozesse im Herzen in Folge von myokardialem Infarkt (MI) mittels cDNA Makroarrays …
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An optimized CAM-8 simulator for the SPARC architecture
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1992.
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The design of a high performance SPARC bus interface
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.
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ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… cell was found to secrete a high level of SPARC which significantly stimulated the expression of BMP7 in bone marrow stromal cells (BMSC). The secreted BMP7 then kept cancer cells in a dormant state by inducing senescence, reducing stemness and activating dormancy-associated p38 MAPK …
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Investigation of the proteins SPARC and HMGB1 in chronic airways disease
… secreted protein acidic and rich in cysteine (SPARC), mediates the interaction between cells and their surrounding extracellular matrix (ECM) but does not contribute structurally to the matrix. It regulates basic cellular functions such as cell adhesion and proliferation, as well as the …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
… One gene that becomes highly upregulated is SPARC (secreted protein acidic and rich in cysteine). Increased SPARC expression is associated with malignant progression in a variety of different cancers, although little is known regarding the mechanisms of SPARC gene regulation. Therefore, the …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
… potential to regulate the fibrotic response is SPARC (secreted protein acidic and rich in cysteine), a matricellular protein involved in tissue repair, extracellular matrix (ECM) regulation, cellular proliferation, and cellular adhesion. The goal of this project was to determine the role of …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
… potential to regulate the fibrotic response is SPARC (secreted protein acidic and rich in cysteine), a matricellular protein involved in tissue repair, extracellular matrix (ECM) regulation, cellular proliferation, and cellular adhesion. The goal of this project was to determine the role of …
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Mobilization of Adipose Stromal Cells In Obesity and Cancer By Sparc and Its Proteolytic Isoforms
… binding of the matricellular protein SPARC to β1 integrin on ASC surface induces their motility. Here, we demonstrate that absence of SPARC diminishes ASC capacity to mobilize. As adiposity correlates with circulating SPARC and is the major producer of it, we evaluate SPARC level in …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
<p>THE ROLE OF THE SPARC ACIDIC DOMAIN AND EGF-LIKE MODULE IN GLIOMA MIGRATION, INVASION, AND SIGNALING</p> <p>HEATHER M. MCCLUNG</p> <p>Advisor: Sandra A. Rempel, Ph.D.</p> <p>Major: Pharmacology</p> <p>Degree: Doctor of Philosophy</p> <p>We have previously shown that Secreted Protein Acidic and …
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Investigation of cryogenic cooling for a high-field toroidal field magnet used in the SPARC fusion reactor design
… (TF) magnets of the highly compact, high-field SPARC Version 0 (V0) reactor design. The V0 design is set to operate at magnetic fields as high as 20 T, and operating temperatures ranging from 10-30 K. Due to the increase in range of operating conditions made available through the HTS-based …
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… in part by the matricellular protein SPARC. SPARC expression in human PDA patients correlates with improved chemoresponse; however, the mechanism underlying this is unclear. I proposed that SPARC reduces collagen binding to collagen receptors. Structural studies identified that SPARC …
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The Effect of Exercise-induced Myokines on Placental Health and Function
… human placental explants (N=5) were treated with SPARC in a dose-dependent manner (0-150ng/ml). Metrics of placental health/function, including GLUT-4 expression/regulation, were assessed. Results: 1) Active women demonstrated an elevation in circulating SPARC compared to non-active women …
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Optimal resource allocation In base stations for mobile wireless communications
… power allocation problem with rate constraints (SPARC), the objective of which is to maximise total data transmission rate of the entire system. To design an exact algorithm for the fractional subcarrier and power allocation problem with rate constraints (F-SPARC) problem in order to maximise …
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Persona Reinforcement for Secure Programming AI Tutors: Adaptive Assistance in Action
… Programming with Adaptive Reasoning Companion (SPARC), an AI-powered tutor designed to guide students through secure programming exercises, rather than directly provide solutions. Our design reinforces SPARC's tutor persona through a confluence of three techniques: (1) tailored prompt …
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Measuring the sense of community in a magnet school
… if specific professional development (Project SPARC) enhanced staff commitment to the magnet school's focus. The Royal and Rossi Measures of Sense of Community were administered in the form of a questionnaire to all staff within the school both before and after Project SPARC was offered as a …
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Modeling of Boundary Transport and Divertor Target Heat Flux - Implications for Advanced Divertor Concepts
… to achieve physics breakeven such as ITER and SPARC, the heat flux width is predicted by some estimates to be less than 1 millimeter. It is therefore crucial to develop methods to more accurately predict the heat flux width and to mitigate large heat fluxes. Data from the Alcator C-Mod tokamak …
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Design Techniques for Efficient Sparse Regression Codes
Sparse regression codes (SPARCs) are a recently introduced coding scheme for the additive white Gaussian noise channel, for which polynomial time decoding algorithms have been proposed which provably achieve the Shannon channel capacity. One such algorithm is the approximate message passing (AMP) …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… secreted protein acidic and rich in cysteines (SPARC) as a mediator of OEC-induced outgrowth in vitro. To test the contributions of SPARC to spinal cord repair after OEC transplantation, cultures of LP OECs from SPARC null and wildtype (WT) mice were transplanted into a crush of the dorsolateral …
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Novel biomarker identification in pancreatic cancer using Raman spectroscopy
… and cancerous tissue in the exocrine pancreas. SPARC has been shown to play a role and be expressed in the development of pancreatic cancer and has recently been identified as a potential biomarker for the disease. Raman spectroscopy is an emerging technology, showing promise in the detection …
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