University of Ottawa (Canada)
Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
Abstract
dc:descriptionCD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell activation, and Listeria monocytogenes (LM) which induces massive T cell activation, the influence of T cell stimulation on memory development was discerned. It was hypothesized that muted activation of CD8+ T cells by BCG might result in impaired development of memory. It was found that in contrast to LM naive as well as memory CD8+ T cells undergo delayed and muted expansion and contraction during BCG infection. Memory CD8+ T cells remained functional as they expressed cytokines, killed targets and proliferated in response to antigen. Furthermore, inflammatory cytokines and T cells curtail antigen-presentation during BCG infection which curbs T cell stimulation and favors the development of functional memory.
Degree
thesis:*- Grantor dc:publisher
- University of Ottawa (Canada)
- Year dc:date
- 2013
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Saldanha, Marsha
Subjects
dc:subject × 2Rights
- Language dc:language
- en
Identifiers
dc:identifier.*- Identifier
-
Source: Masters Abstracts International, Volume: 47-06, page: 3415.
http://dx.doi.org/10.20381/ruor-18979 - OAI identifier oai:identifier
- oai:ruor.uottawa.ca:10393/27915