A WIRELESS ELECTRICAL STIMULATION SYSTEMFOR WOUND HEALING THERAPYWITH BIPHASIC HIGH-VOLTAGE PULSED CURRENT OUTPUT

<p>In this research, two wearable surface stimulation systems have been developed for use in wound electrotherapy. These self-contained, battery-powered bandages have been demonstrated in-vivo using both a rat chronic wound model and a pig infected wound model and provide a new means to investigate the physiological mechanisms of wound healing.</p><p>The first stimulation bandage was designed for use with a rat wound model and consists of a stimulator PCB module and plastic electrode bandage. The PCB is constructed from discrete COTS components and is powered by a small button cell battery providing at least seven days of continuous use. This voltage-mode device generates stimulation pulses that are 10 - 90 V in amplitude, 10 - 200 µs in width, and 12 – 25 Hz in frequency. Stimulation was typically applied to wounds for 10 minutes every hour for one week, and then the device and wound dressings were replaced. </p><p>An ASIC has been developed using the OnSemi 0.7-µm I2T100 process and iscapable of operation up to 100 V. A high-gain, current-mode boost converter addresses challenges associated with efficient generation of the large amplitude compliance voltage (up to 90 V) from a small battery with limited output current capability. A biphasic current mode stimulator was demonstrated with ±21-mA output range, 0.33-mA resolution, and a voltage headroom requirement of 3.5 V at full scale output.</p><p>The second stimulation bandage uses this ASIC and was designed for use on larger wounds, up to 6 cm in diameter. A rechargeable lithium polymer battery allows a single stimulator module to be used for an entire 28-day study. The disposable electrode bandage portion of the device is easily replaced in-situ by the clinician. Continuous monitoring of the delivered stimulation current while the device is in place on an animal is achieved using a microcontroller with a built-in Bluetooth Low Energy radio. Performance information from up to six devices is recorded to a wireless base station located outside the animal pen and may also be remotely accessed by research personnel. </p>

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

EECS - Electrical Engineering

Grantor dc:publisher

Case Western Reserve University School of Graduate Studies

Year dc:date

2013

Author dc:creator

• Howe, Daniel Steven

Contributors dc:contributor

• Garverick, Steven

• Electrical Engineering
• Health Care
• Biomedical Engineering
• Wound Healing
• Electrical Stimulation, Stimulator
• HVPC
• Wireless
• Bluetooth
• ASIC
• PCB
• Boost Converter

Statement dc:rights

• unrestricted
• This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

Language dc:language

English

Repository record dc:identifier

http://rave.ohiolink.edu/etdc/view?acc_num=case1365179992

OAI identifier oai:identifier

oai:etd.ohiolink.edu:case1365179992