Characteristics and usefulness of interfascicular contacts in peripheral nerve recording

Neural interfaces have been used in conjunction with source separationalgorithms to address the challenge of extracting useful command signals fromnerves. A peripheral nerve interface is generally useful for signal extraction if it (1) exhibits favorable recording characteristics such as signal-to-noise ratio and (2) provides as many independent channels of neural information as possible. We investigated the usefulness of novel interfascicular electrodes in acute experiments on the rabbit sciatic nerve (n = 4). Directed interfascicular contacts were found to record compound action potentials (CAPs) with a meanSNR (at p = 0.05) of 24.5 dB with respect to interference sources. Contacts that (1)faced opposite directions and (2) were placed in various positions within theepineurium were found to record independent information from the nerve (mixing matrix |det(H)|>0.05 for all electrode configurations). This neuralinformation recorded using interfascicular electrodes may potentially be useful forcommand signal extraction algorithms.

Name thesis:degree_name

Master of Sciences (Engineering)

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Biomedical Engineering

Grantor dc:publisher

Case Western Reserve University School of Graduate Studies

Year dc:date

2013

Author dc:creator

• Kolb, Ilya

Contributors dc:contributor

• Tyler, Dustin

• Biomedical Engineering
• Neurology
• Neurosciences
• interfascicular
• peripheral nerve
• neural recording
• source separation

Statement dc:rights

• unrestricted
• This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

Language dc:language

English

Repository record dc:identifier

http://rave.ohiolink.edu/etdc/view?acc_num=case1347309212

OAI identifier oai:identifier

oai:etd.ohiolink.edu:case1347309212