Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling

<p>This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent fashion. Increases in extracellular connective tissue occurred concomitantly with arterial remodeling. Wall thickness to lumen diameter ratios did not change in any vessel at any time when compared to controls, suggesting normalization of flow-induced wall stress through vascular remodeling.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Year dc:date.available

1997

Author dc:creator

• Tulis, David Anthony

Contributors dc:contributor

• Russell L. Prewitt
• Stephen J. Beebe
• Mark S. Elliot
• Thomas J. Lauterio
• Paul H. Ratz

• Arteries
• Vascular remodeling
• Nitric oxide
• Animal Structures
• Biophysics
• Cardiovascular System
• Physiology
• Surgery

Identifier

9780591603989

OAI identifier oai:identifier

oai:digitalcommons.odu.edu:biomedicalsciences_etds-1088