REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5

OBESITY AND ASSOCIATED METABOLIC DISORDERS ARE MAJOR THREATS TO PUBLIC HEALTH. THE MECHANISMS THAT LEAD TO OBESITY-ASSOCIATED METABOLIC DISORDERS HAVE NOT BEEN WELL UNDERSTOOD. HERE, WE DISCOVERED TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE DEVELOPMENT OF OBESITY AND TYPE 2 DIABETES. MICE DEFICIENT IN IRF3 DEVELOPED OBESITY AND TYPE 2 DIABETES WHICH IS ASSOCIATED WITH INCREASED ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION. FOR MKP5, WE FOUND IT PROTECTIVE IN THE DEVELOPMENT OF HEPATIC STEATOSIS. MICE DEFICIENT IN MKP5 DEVELOPED HEPATIC STEATOSIS, WHICH WAS ASSOCIATED WITH INCREASED P38 MAPK ACTIVITY IN THE LIVER. FURTHERMORE, MKP5 REGULATES THE EXPRESSION OF CIDEA AND FSP27, TWO GENES IMPORTANT FOR THE DEVELOPMENT OF HEPATIC STEATOSIS. THEREFORE, BOTH IRF3 AND MKP5 PLAYS COULD

Author dc:creator

• TANG PENG

• Obesity,Adipogenesis,Inflammation,hepatic steatosis,IRF3,MKP5