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University of North Dakota
Analysis Of Yscf And Associated Homologs And The Presence Of An Inflammatory Molecular Pattern
Abstract
dc:description.abstract<p>Gram-negative pathogen, Yersinia pestis, expresses a type three secretion system to accomplish its virulence. The YscF needle protein provides a conduit of effectors from bacterium to eukaryote and is exposed to the host immune system. This thesis explores YscF and its associated needle homologs and the possibility of recognition as pathogen-associated molecular patterns (PAMP) by macrophage tissue culture. Interestingly, Salmonella homologs PrgI and SsaG are inflammatory suggesting conservation of the inflammatory pattern in the T3SS needle protein.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science (MS)
- Level thesis:degree_level
- Thesis
- Discipline thesis:degree_discipline
- Biomedical Sciences
- Year
- 2012
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Roughead, William Andrew
- Contributors dc:contributor
-
- Matthew L. Nilles
Subjects
dc:subject × 1Identifiers
dc:identifier.*- Repository record dc:identifier
- https://commons.und.edu/theses/1316
- OAI identifier oai:identifier
- oai:commons.und.edu:theses-2317