High throughput analysis to study emerging pollutants and nanoparticle fate in biological systems

<p>”The increasing applications of emerging and fugitive contaminants (EFCs) and engineered nanoparticles (ENPs) attract significant research interest for their potential risks to human health and the environment. In order to assess the health risks of these emerging contaminants, rapid and reliable analytical methods to measure the concentrations and fates of these contaminants are imperative. This dissertation focuses on the developments of advanced analytical methods and their applications to study those emerging contaminants in crop plant and simulated gastric fluid (SGF). Three types of mass spectrometry based methodologies have been developed, one is freeze-thaw/centrifugation extraction followed by high performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS) method for non-volatile EFCs analysis in three species of crop plant and one is freeze-thaw-equilibration head space-solid phase microextraction (SPME) followed by gas chromatography-mass spectrometry (GC-MS) method for volatile EFCs analysis in three species of crop plant; and one is single particle-inductively coupled plasma-mass spectrometry (SP-ICP-MS) method for ENPs analysis in SGF. By using these SP-ICP-MS methods, various factors such as species, size, concentration of ingested ENPs, and body temperature on the fates of nanoparticles in the digestion system were investigated.</p> <p>The studies in this dissertation offer green analyses with high throughput analytical methods for EFCs and ENPs. It represents significant advancement and contribution in rapid screening the concentrations of EFCs and ENPs, as well as understanding fates of EFCs and ENPs in biological systems, therefor will make significant contributions to environment research, food security, and human health”--Abstract, page iv.</p>

Name thesis:degree_name

Ph. D. in Chemistry

Grantor

Missouri University of Science and Technology

Author dc:creator

• He, Xiaolong

• EFCs and ENPs
• Food safety
• Human health
• LC-MS/MS&GC/MS
• Method development
• SP-ICP-MS
• Analytical Chemistry
• Biochemistry
• Environmental Health

Repository record dc:identifier

https://scholarsmine.mst.edu/doctoral_dissertations/3096

OAI identifier oai:identifier

oai:scholarsmine.mst.edu:doctoral_dissertations-4101