Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"HPLC-MS/MS"”.
-
Die Aufklärung der Biogenese strukturell ungewöhnlicher Alkaloide aus Triphyophyllum (Dioncophyllaceae) und Antidesma (Euphorbiaceae) und Entwicklung und Einsatz der "Triade" zur phytochemischen Online-Analytik: HPLC-MS/MS, HPLC-NMR und HPLC-CD
… die methodische Verbesserung der online-"Triade" HPLC-MS/MS, HPLC-NMR und HPLC-CD im Vordergrund. Diese neuen Techniken dienten im Anschluß der phytochemischen Untersuchung verschiedener Pflanzenextrakte. Nach der erstmaligen online-Analyse von Ancistrocladus griffithii wurden drei neue Alkaloide, …
-
Advanced analytical strategies to determine biomedical parameters for medical diagnostics, drug delivery, and therapy
… chromatography - tandem mass spectrometry (HPLC-MS/MS), and 3) nuclear magnetic resonance (NMR) studies of porous wall hollow glass microspheres (PWHGMs) that have the potential to be used as drug delivery carriers. Firstly, a dual-core fiber-optic pH micro-probe was developed which can be …
-
Zuckerphosphate als Vorläufer von 4-Hydroxy-3(2H)-furanonen - Biochemische Transformation durch die Hefe Zygosaccharomyces rouxii und chemische Bildung unter physiologischen Bedingungen
… in denen der Einfluss verschiedener Wachstumsbedingungen auf die HDMF-Bildung durch Z. rouxii getestet wurde, zeigten bezüglich der HDMF-Bildung ein pH-Optimum bei pH 5.1 sowie eine maximale Produktivität der Zellen bei einer NaCl-Konzentration von 20%. Mittels einer neu entwickelten …
-
Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices
… liquid chromatography tandem mass spectrometry (HPLC-MS/MS), analyte retention and sensitivity are increased after derivatization, 6.7-fold for glufosinate and 6.3-fold for 3-MPPA. TrEnDi methodology was applied to canola samples from two separate fields sprayed with Liberty®. Prior to …
-
β-Sitosterol Isolated from Theobroma Cocoa Induces the Expression Of Mkp-1 and Il-10 In Trigeminal Neurons
… was identified as β-sitosterol based on NMR and HPLC/MS/MS data. The anti-inflammatory mediators MKP-1 and IL-10 were up-regulated in trigeminal neurons in a concentration-dependent manner by β-sitosterol. A somewhat surprising finding from my study was that the active compound β-sitosterol …
-
The Toxicokinetic Behavior of Cyanide, Thiocyanate and 2-Amino-2-Thiazoline-4-Carboxylic Acid Following Cyanide Exposure in Multiple Animal Models Utilizing Novel Methods of Detection
… gas-chromatography mass-spectrometry (CI-GC-MS) and high-performance liquid chromatography tandem mass-spectrometry (HPLC-MS-MS). The CI-GC-MS method produced limits of detection (LOD) of 1 μM and 50 nM with linear dynamic ranges of 10 μM-20 mM and 500 nM-200 μM for cyanide and thiocyanate, …
-
Assessing the role of probiotics for the enhancement of soil quality under cover crops
… (anhydrous) use. Soils at the study site were Armstrong loam (fine, smectitic, mesic Aquertic Hapludalfs). The treatments included: control, treatment 1 (Trt1; 60L ha-1 yr-1 of Bio-Ag probiotics), treatment 2 (Trt2; 90L ha-1 yr-1 of Bio-Ag probiotics) and treatment 3 (Trt3; 120L ha-1 yr-1 of …
-
Bio-enrichment of vitamin B12 in plant-based food via fermentation
… were quantified using microbiological assays and HPLC-MS/MS during both strain selection and fermentation. Additionally, genetic analyses were conducted to investigate gene clusters involved in B12 biosynthesis and their regulation. Only a limited number of Lactobacillus strains produced …
-
ESTABLISHING PTERIDINE METABOLISM IN A BREAST CANCER CELL MODEL AND QUANTIFICATION OF SILVER NANOPARTICLE INTERACTIONS WITH YEAST CELLS USING MASS SPECTROMETRY
… of the research presented, a recently developed HPLC-MS/MS method was advanced to elucidate pteridine metabolism in an isogenic progressive MCF10A breast cancer cell model. The folate-derived pteridine pathway in breast cells was established by individually dosing cell cultures with folic acid …
-
EFFECTS OF MATURITY STAGES AND GROWING CONDITIONS ON PHYTOCHEMICAL PROFILE AND ANTIOXIDANT ABILITY OF BRASSICA VEGETABLES
… and mature kale harvested at 87th day using a HPLC-MS/MS method, with trisinapoyl-diglucoside, quercetin-3-sinapoly-diglucoside-7diglucoside, feruloyl-glucoside, and disinapoyl-diglucoside being the primary components in each, respectively. The aliphatic glucosinolates including sinigrin and …
-
Investigation of biomarkers for noninvasive early diagnosis of cancer
… them to 68 normal samples using a validated LC/MS/MS method. Statistical analysis showed that the above biomarkers were not reliable enough for prostate cancer detection or for differentiating the aggressiveness of prostate cancer. The third study describes a validated, reliable, fast, and …
-
Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
… and sensitivity of tandem mass spectrometry (MS/MS) with the high separation ability of high performance liquid chromatography (HPLC) facilitates the sensitive and specific analysis in complex matrices like urine and blood. In this body of work, new methods were developed using CE-UV, CE-LIF …
-
High throughput analysis to study emerging pollutants and nanoparticle fate in biological systems
… chromatography - tandem mass spectrometry (HPLC-MS/MS) method for non-volatile EFCs analysis in three species of crop plant and one is freeze-thaw-equilibration head space-solid phase microextraction (SPME) followed by gas chromatography-mass spectrometry (GC-MS) method for volatile EFCs …
-
Veränderungen in Proteom und Metabolismus bei dilatativer Kardiomyopathie Cathepsin L defizienter Mäuse
… Proteine mittels MALDI-TOF und Nanoflow-HPLC/MS/MS identifiziert. 5 dieser Proteine sind Bestandteile der Atmungskette, 5sind Stressproteine und 12 sind am Metabolismus beteiligt. Die Atmungskettenproteinesind Teile der Komplexe I, III, IV und V und sind im Durchschnitt um 40% …
-
Milk protein adulteration detection via mass spectra and infrared spectroscopy
… to guarantee food safety. The current thesis aims to test and compare methods such as two-dimensional gel electrophoresis (2-DE), liquid chromatography tandem mass spectrometry, and infrared spectroscopy to detect foreign protein spiked in milk, especially hydrolyzed plant proteins. Here are the …
-
UNVEILING THE ADVERSE EFFECTS OF POLYSTYRENE NANOPLASTICS IN THE HUMAN-DERIVED HEPG2-OA STEATOTIC-LIKE MODEL, VALIDATING DYSFUNCTIONAL HUMAN-DERIVED SW872 ADIPOCYTE IN VITRO MODELS FOR THE STUDY OF CARDIOMETABOLIC DISEASES, AND ASSESSING TRIMETHYLAMINE N-OXIDE IN A PLIC STUDY SUB-COHORT
… protonica (1H NMR) e la spettrometria di massa (MS) accoppiata alla cromatografia liquida ad alta prestazione (HPLC). Nonostante la robustezza di un ampio spettro di metodi analitici per misurare il TMAO da campioni di plasma o siero di origine umana utilizzando queste piattaforme, sussiste …
-
Sviluppo di tecniche di analisi ifenate per la quantificazione di biomarcatori di esposizione a tossici ambientali: gli acidi mercapturici
… to electrospray ionisation-mass spectrometry (μHPLC-ESI-MS/MS) method for the simultaneous quantitative detection of the BTX exposure biomarker SPMA, SBMA and o-MBMA in human urine. Urinary S-phenylmercapturic acid (SPMA) is a biomarker proposed by the American Conference of Governmental …
-
Plasma concentrations of nelfinavir and viral suppression in HIV-1 infected pregnant women
… recorded and drug levels were measured using HPLC MS-MS. NFV concentration-ratios(NFV-CRs) were calculated by dividing individual levels by a time-adjusted population value. Plasma NFV concentrations and NFV-CRs were compared across gestational age and correlated to variables of interest. Rate …
-
QTL discovery for Japanese beetle resistance in aphid-resistant germplasm, stacking aphid-resistant genes, and metabolite profiling studies in soybean
… to insect defoliators. In order to improve MSU aphid-resistant germplasm for resistance to Japanese beetle (<Popillia japonica> Newman), a population was derived from a cross between E06906 (MSU) and another aphid-resistant source, LD05-16060 (Uni. of Illinois) that showed lower …
-
Proteomic Analysis of the Blood of <i>Alligator mississippiensis</i>
… methods to understand their innate immune systems. The first goal was to sequence peptides and proteins from the blood serum and leukocytes using tandem mass spectrometry and <i>de novo</i> sequencing. The second goal was to determine the function of these biological molecules and their …
Page 1 of 2