The role of the CB1 receptor in learning, memory and anxiety-like behaviors

Several lines of evidence support a role of the endocannabinoid (eCB) system in cognition and anxiety. This study explores cognitive processes and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. No differences were observed in the Open-Field task, suggesting that the observed behavioral differences may be related to anxiety rather than cognitive impairments. This study has important implications for neuropsychiatric disorders, including depression and post-traumatic stress disorder.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Grantor dc:publisher

University of Montana

Year

2009

Author dc:creator

• Bolyard, Loretta Lynn

• age
• anxiety
• CB1 receptor
• endocannabinoid
• learning
• memory

Repository record dc:identifier

https://scholarworks.umt.edu/etd/1074

OAI identifier oai:identifier

oai:scholarworks.umt.edu:etd-2093