Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"endocannabinoid"”.
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Endocannabinoid regulation of gastric vagal afferent signalling
… show decreased GVA tension receptor sensitivity. Endocannabinoids (ECs) regulate appetite via cannabinoid 1 (CB1) receptors and are also endogenous ligands for TRPV1. The CB1 receptor and TRPV1 are expressed on GVAs and the CB1 receptor is also expressed on gastric ghrelin cells. Further, the …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
<p>The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol …
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Role of the Endocannabinoid System in Cardiac Remodeling
The endocannabinoid system and CB1 and CB2 cannabinoid receptors have been implicated in cardiac remodeling with CB1 inhibition and CB2 activation reported to be beneficial. However, the role of these receptors in cardiac remodeling secondary to hypertension is not known. Moreover, the functions of …
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Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
… (DAGL α and β) synthesise 2-AG, the major endocannabinoid (eCB) in the developing and adult brain. 2-AG acts most prominently on the CB1 and CB2 receptors and growing evidence points to a role of eCB signaling in adult neurogenesis as well as a wide range of different physiological roles in …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… Dietary EPA and DHA are converted to omega-3 endocannabinoids (eCBs), eicosapentaenoicethanolamide (EPEA) and docosahexaenoicethanolamide (DHEA), respectively. Subsequently, omega-3 eCBs are substrates for eicosanoid-synthesizing enzymes, cyclooxygenase, lipoxygenase and cytochrome P450 …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as important modulators of synaptic plasticity but their precise roles and mechanisms are not well understood and many contradictions exist in the current literature. We have investigated the roles of …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as important modulators of synaptic plasticity but their precise roles and mechanisms are not well understood and many contradictions exist in the current literature. We have investigated the roles of …
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Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
… due to its actions as a transporter of the endocannabinoid/ endovanilloid, anandamide (AEA). Regulation of synaptic AEA concentrations is critical to homeostatic control of neurotransmitter release since AEA can act both at CB1Rs, to depress neurotransmission, and TRPV1 channels, to enhance …
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Blood Pressure Regulation by the Endocannabinoid System in Conditions Associated with Hypertension
Hypertension is associated with various conditions including obesity, type II diabetes and aging. Despite decades of research, the mechanisms involved in the development of hypertension are still poorly understood. Emerging evidence suggests hypertension is mediated by an imbalance in autonomic …
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Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
… conditioning procedures. Conversely, enhancing endocannabinoid signaling, via genetic deletion of the FAAH enzyme, accelerated acquisition of the task under aversive, but not appetitive, conditioning procedures. Accordingly, these data strongly support the hypothesis that the endogenous …
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Modulation of Fatty Acid-Induced Skeletal Muscle Inflammation by the Peripheral Endocannabinoid System.
The endocannabinoid system (ECS) has classically been known as a major neuromodulatory system of the central nervous system, in which endocannabinoids act as retrograde neurotransmitters that inhibit synaptic activity. However, recent evidence has indicated that the ECS may also play a key role in …
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Mouse Models of GRIN1-Related Neurodevelopmental Disorder and Initial Investigations of Endocannabinoid Modulating Treatments
… to test potential treatments which modulate the endocannabinoid system. Additionally, de-identified patient data was collected to examine the representative nature of these mice in modelling specific aspects of patient symptomology. Grin1Y647S/+ and Grin1Q536R/+ displayed alterations to GluN1 …
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Investigating Endocannabinoid Metabolism in Alcohol Use Disorder: a focus on fatty acid amide hydrolase (FAAH)
The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a therapeutic target for Alcohol Use Disorder (AUD) and psychiatric illnesses. Studies suggest that FAAH regulates alcohol intake/preference, and its impairment increases risk for alcohol use disorder (AUD). This …
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Systemic Blockade of the Endocannabinoid System Alters Gene Expression and acquisition of a Hippocampus Dependent Learning Task
Thesis under the direction of Robert Hampson, Ph.D., Associate Professor of Physiology and Pharmacology It has been established that the administration of Δ9-THC and other cannabinoid agonists results in disruptions in learning and memory (Sullivan, 2000). The ability of rimonabant to reverse …
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Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… drive the formation of a neointima. Cannabinoids/endocannabinoids have been shown to elicit antiproliferative, anti-migratory and anti-inflammatory effects, highlighting modulation of the endocannabinoid system as possible therapeutic strategy. The aims of this study were to; (i) develop an organ …
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A Phenomenological Inquiry into Healthcare Professionals Who Are Experts in Cannabinoid Therapy and the Endocannabinoid System (ECS)
… data has affected cannabinoid therapy and endocannabinoid system education (ECS) for healthcare professionals. There are gaps in medical school and continuing medical education initiatives despite the increase in cannabis consumption. As a result, healthcare professionals at all levels from …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… Accumulating evidence suggests that the endocannabinoid system represents a promising therapeutic target for CIPN, given its key role in pain regulation and the favourable tolerability profile of cannabinoids or endocannabinoid system modulators in patients with chronic pain. Both pain …
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Endocannabinoid and lipid metabolism genes network analysis in adipose and liver tissue of dairy cows during the transition period
… 1) effects of body condition score (BCS) on the endocannabinoid system and lipid metabolism gene expression in adipose tissue; and 2) effects of rumen-protected methionine on the endocannabinoid system in liver tissue. In the first study, cows were retrospectively classified according to their …
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