Splenic Regulation Of Macrophage Activity In Mice Infected With Listeria Monocytogenes

Splenectomized mice are more resistant than normal mice to challenge by Listeria monocytogenes. The regulatory role of the spleen over macrophage activation in mice was investigated. The macrophage migration inhibition test was used to measure in vitro macrophage activity. Macrophages from splenectomized, infected mice were shown to have increased migration and therefore increased activation over macrophages from normal infected mice. The effect of plasma from Listeria infected mice on splenectomized mice was tested. It was shown that immune plasma had no effect on macrophage migration. Results indicate the macrophage is responsible for increased resistance to Listeria infection in the splenectomized mouse. The increased activation seen could result from an increase in migration inhibitory factor (MIF) production or the production of macrophage activation factor (MAF) or both. A possible role for MIF, MAF, and B cells is discussed.

Name thesis:degree_name

Master of Science in Biology

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Biology

Year

1980

Author dc:creator

• Cavender, Nancy Ann

Contributors dc:contributor

• Richard Myers

• Biology

Statement dc:rights

• © Nancy Ann Cavender

Repository record dc:identifier

https://bearworks.missouristate.edu/theses/997

OAI identifier oai:identifier

oai:bearworks.missouristate.edu:theses-1998