Evaluation of layer-by-layer assembly of polyelectrolyte multilayers in cell patterning technology

The layer-by-layer assembly of polyelectrolytes into multilayered films is an attractive approach for fabricating novel biomaterials, as it offers tremendous control over the internal composition and surface properties of their layered architectures. In this work, polyelectrolyte multilayers (PEMs) were evaluated as a platform for applications in controlling the spatial adhesion of living cells. An overview is presented on current developments and competing technologies within research and industry with respect to cell patterning and cell-based devices. Interviewed individuals in research and industry suggested a variety of potential applications of PEMs in cell patterning technology. A patent search on the core technologies (i.e. PEMs and patterning methods) and on applications in cell patterning, cell-based screening, and cell-based biosensors revealed ample opportunity for starting a new venture with a platform based on the layer-by-layer assembly of PEMs. A brief business plan for starting a new venture with a platform based on the layer-by-layer assembly of PEMs is proposed to initially target the high throughput screening and cell-based biosensor markets.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2002

Author dc:creator

• White, Aleksandr John, 1976-

Advisor dc:contributor.advisor

• Michael F. Rubner.

• Materials Science and Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/8426

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/8426