Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Polyelectrolyte multilayers"”.
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Biological applications of weal polyelectrolyte multilayers
… on biological applications of ultra-thin weak polyelectrolyte multilayers with specific emphasis on cell patterning, drug delivery, and antibacterial coatings. All of these very different applications were studied using three different polymers - polyacrylic acid (PAA), poly(allylamine …
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Polyelectrolyte multilayers for plasmonics and picosecond ultrasonics
This thesis investigates the application of polyelectrolyte multilayers in plasmonics and picosecond acoustics. The observed samples were fabricated by the spin-assisted layer-by-layer deposition technique that allowed a precise tuning of layer thickness in the range of few nanometers. The first …
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Fundamental studies of pH-sensitivity in polyelectrolyte multilayers
… of the pH-sensitive behavior of weak polyelectrolytes, such as poly(acrylic acid)(PAA) and poly(allylamine hydrochloride) (PAH) from two perspectives of the assembled multilayers - functional group composition and layer growth. In the first part of this thesis, with respect to the …
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Polyelectrolyte multilayers as nanostructured templates for inorganic synthesis
… and mediating this interaction and organization. Polyelectrolyte multilayers formed by the layer-by-layer electrostatic assembly of oppositely charged polymers are a versatile new form of thin film in which the physical and chemical architecture can be precisely controlled over the nanoscale. This …
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Polyelectrolyte multilayers : nanofabricated architectures for bio-interface materials
… such as enzymes and DNA, has expanded the use of polyelectrolyte multilayers for biosensor and other biomaterials applications. This thesis further explores the rationale of using multilayers as biomaterials, with particularly emphasis on the importance of the underlying molecular architecture. …
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The Design of Polyelectrolyte Multilayers Using Galactosylated Chitosan
… via a specific receptor-ligand interaction. Polyelectrolyte multilayers (PEMs) were prepared by the layer by layer method, which is based on electrostatic attractions between oppositely charged polyelectrolytes (PEs). Anionic (hyaluronic acid) and cationic (chitosan and galactosylated …
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Fabrication and structural studies of sequentially adsorbed polyelectrolyte multilayers
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1997.
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Inhibition of biofilm growth on highly polycationic polyelectrolyte multilayers
The epithelial cell adhesion molecule E-cadherin is often down regulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I …
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Polyelectrolyte multilayers for tunable release of antibiotics and other therapeutics
Polyelectrolyte multilayers (PEMs) were fabricated via the layer-by-layer (LbL) deposition process, incorporating hydrolytically degradable poly([beta]-amino esters) to result in biodegradable PEMs that can release active ingredients in a dosage- and rate-tunable fashion. Specifically, PEMs …
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PH-gated porosity and reversible swelling transitions in polyelectrolyte multilayers
… explores the design of novel pH-responsive polyelectrolyte multilayer (PEM) films. The discoveries of discontinuous pH-induced swelling transitions and concomitant conformational memory effects as well as pH-gated nano- and microporosity in PEMs, are described. The PEMs in this thesis are …
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Polyelectrolyte multilayers (PEM) in micro / nanofluidics for novel BioMEMS platforms
… thesis was to exploit the versatility of the polyelectrolyte multilayer (PEM) to fabricate a novel micro/nanofluidic device for patterning bacteria in BioMEMS. Nanofluidic channels offer new opportunities for advanced biomolecule manipulation and separation science because they provide unique …
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Influence on molecular geometry and chain conformation on properties of polyelectrolyte multilayers
The layer-by-layer (LbL) method of self-assembly is a versatile technique for fabricating thin polymer films. This thesis compares the properties of LbLfilms composed of different weak polycations. Slight perturbations in film assembly conditions can lead to large differences in film properties. …
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Attachment of polyelectrolyte multilayers to cells and the implications on cell behavior
The development of targeted drug delivery systems is of fundamental importance for the transport of highly toxic drugs to diseased cells. One way of achieving this is using biohybrid materials, which integrates synthetic components with cells in order to confer unique properties to existing …
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Controlled release of gentamicin from polyelectrolyte multilayers to treat implant-related infection
Polyelectrolyte multilayered (PEM) coatings were fabricated to incorporate and release the small, hydrophilic antibiotic gentamicin from implant surfaces for infection control. The use of a cationic hydrolytically cleavable poly(p-amino ester) rendered these films biodegradable, yielding both …
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Polyelectrolyte multilayers incorporating photocrosslinking polymers for controlling 2- and 3-dimensional structure
Polyelectrolyte multilayer (PEM) assembly is a technology for building thin films with a number of useful and novel functionalities. PEMs interact favorably with proteins and other biomolecules making them potentially valuable as biomaterials. Many systems of polymers have been studied for use in …
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Improving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers
… The first aim focuses on developing polyelectrolyte multilayers (PEMs) using tanfloc (TAN), an amphoteric antimicrobial polymer, as both a polycation and polyanion. These PEMs showed strong antibacterial activity and excellent biocompatibility, providing a foundation for …
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Evaluation of layer-by-layer assembly of polyelectrolyte multilayers in cell patterning technology
The layer-by-layer assembly of polyelectrolytes into multilayered films is an attractive approach for fabricating novel biomaterials, as it offers tremendous control over the internal composition and surface properties of their layered architectures. In this work, polyelectrolyte multilayers (PEMs) …
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The Design of Three-Dimensional Multicellular Liver Models Using Detachable, Nanoscale Polyelectrolyte Multilayers
… transparent chitosan and hyaluronic acid (HA) polyelectrolyte multilayer (PEM) film. The properties of the PEM were tuned to mimic the Space of Disse found in liver. The thickness of the detachable PEM was 650 to 1000 nm under hydrated conditions. The Young's modulus of the PEM was …
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Selective growth of magnetic nanoparticles in domains of block copolymer films, and in polyelectrolyte multilayers
… nanoparticles have also been produced inside polyelectrolyte films by the growth of palladium nucleating sites followed by the use of an electroless plating bath. Control of particle size and spatial distribution has been demonstrated. The effect of electroless bath chemistry on particle …
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Assembly and post-assembly manipulation of polyelectrolyte multilayers for control of bacterial attachment and viability
… thesis was to exploit the versatility of the polyelectrolyte multilayer (PEM) platform to consider bacteria-substrata interactions by varying multilayer assembly and post-assembly conditions. We developed multiple PEM systems to probe the ability of substrata to resist bacteria attachment or …
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