Protein and viral partitioning in two-phase aqueous micellar systems

These changes included an expanded pattern of labeling and a large increase in the density of labeling. Changes were seen not only in primary auditory cortex, but also in other cortical fields that have not been studied before. In contrast, there was little change in brainstem (inferior colliculus, dorsal and anteroventral cochlear nucleus) labeling. Second, the effect of past sound exposure on brain response to sound was examined. After daily exposure to a sound, labeling evoked by that sound was markedly decreased in cortex, but not in brainstem. In two very different conditions, hearing loss and prior sound exposure, we found the same answer: cortical Fos labeling was highly changed, whereas brainstem labeling was more stable. The results suggest that the effects observed in cortex do not reflect subcortical changes and that the multiple fields of auditory cortex are malleable in ways that brainstem auditory nuclei are not. Competitive inhibition and partitioning studies were conducted to investigate possible attractive interactions between the C10E4 micelles and the tailspikes/capsids of bacteriophage P22 (model virus). These possible attractive interactions were investigated because they could counter the effect of the excluded-volume interactions. However, the attractive interactions between the bacteriophage P22 particles and the C10E4 micelles were found to be negligible.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2001

Author dc:creator

• Kamei, Daniel Takashi, 1972-

Advisor dc:contributor.advisor

• Daniel Blankschtein and Daniel I.C. Wang.

• Chemical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/82757

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/82757