Injectable polymer for in vivo oxygen sensing

This thesis documents the synthesis and characterization of an elastomeric polymer that is oxygen sensitive and can be interrogated using Magnetic Resonance Imaging (MRI) or Magnetic Resonance (MR) technology to report the oxygen tension in vivo at the site of implant. The polymer was tested for its sensitivity in response to oxygen, and the specificity of response to oxygen was verified. Oxygen diffusivity for this class of polymers was measured and correlated with the response sensitivity to oxygen to provide a possible explanation for the difference in response sensitivities within this class of polymers. Animal experiments were carried out in rats to test the performance of these sensors in vivo where device response to varying levels of inspired oxygen was monitored.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2013

Author dc:creator

• Imaad, Syed M. (Syed Muhammad)

Advisor dc:contributor.advisor

• Michael J. Cima.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/79228

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/79228