Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"oxygen sensing"”.
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Injectable polymer for in vivo oxygen sensing
… of an elastomeric polymer that is oxygen sensitive and can be interrogated using Magnetic Resonance Imaging (MRI) or Magnetic Resonance (MR) technology to report the oxygen tension in vivo at the site of implant. The polymer was tested for its sensitivity in response to oxygen, and …
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Comparative hypoxia responses and oxygen sensing in galaxiid fishes
… are inherently characterised by limited oxygen availability and fluctuations in dissolved oxygen concentration, and therefore, environmental hypoxia (i.e. low oxygen conditions) is common. However, in recent decades, the frequency and global expansion of hypoxic environments have …
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The Development Of Mems-Based Implantable Oxygen Sensing Systems
Oxygen-based cues are direct assessments for a wide range of in vivo biological effects, ranging from mitochondrial disease to tissue engineering/regenerative medicine. Existing electrochemical oxygen sensors are permanent systems applicable to short-term intraoperative use; devices are extracted …
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The development and evolution of vertebrate oxygen-sensing cells
Oxygen-sensing cells release neurotransmitters, including serotonin, in response to hypoxia in the blood or surrounding air/water. This stimulates the glossopharyngeal and/or vagal nerves, triggering increased ventilation via the respiratory reflex. In the adult, they are located in the carotid …
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Supramolecular quantum dot-porphyrin assemblies for biological oxygen sensing
… characterized by hypoxia, the concentration of oxygen is an important indicator of tumor health. Understanding how this parameter changes as a function of disease progression is critical to develop novel targeted therapeutics. New non-invasive sensors must be developed that are small enough to …
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Phosphorescent semiconductor nanocrystals and proteins for biological oxygen sensing
Oxygen is required for cellular respiration by all complex life making it a key metabolic profiling factor in biological systems. Tumors are defined by hypoxia (low pO2), which has been shown to influence response to radiation therapy and chemotheraphy. However, very little is known about …
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DNMT3a Epigenetic Program Regulates the HIF-2alpha Oxygen Sensing Machinery
… the regulation of hypoxia-inducible factor (HIF) oxygen-sensing machinery. We show that DNA methyltransferase 3a (DNMT3a) methylates and silences the HIF-2alpha gene (EPAS1) in normal cells. Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene program associated with hypoxic …
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New water-soluble porphyrins for oxygen sensing in protein-based materials
Oxygen is a vital molecule for life and its precise quantification is pivotal to ensure correct functioning of cells. Instruments able to quantify accurately the oxygen levels are extremely important to understand cells behaviour especially in a three-dimension (3D) environment, where uneven …
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Oxygen Sensing by the Aer and Tsr Receptors of Escherichia Coli
<p><em>Escherichia coli</em> senses the oxygen concentration of its environment via the Aer and Tsr receptors, and swims to an oxygen concentration that provides optimal energy generation. Aer and Tsr do not sense oxygen per se but, sense the internal energy state via the electron transport system …
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Development of an integrated microfluidic platform for oxygen sensing and delivery
… technology was developed capable of generating oxygen directly from water present in blood plasma. This technology is intended to provide a self-contained, mobile oxygen supply suitable for implantation or extracorporeal oxygenation in support of an acute or chronically disabled lung. The core …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
Non-alcoholic fatty liver disease (NAFLD) is a growing healthcare challenge, affecting ~30% of the global population, however there are currently no specific treatments approved for the disease. A better understanding of pathophysiological mechanisms is required, including the close links between …
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The Role of Mitochondria in Oxygen Sensing of the Ductus Arteriosus and Fetal Pulmonary Arteries
Rationale: Mitochondria underlie the oxygen responses of the ductus arteriosus (DA), adult pulmonary arteries (PA) and other oxygen sensing tissues. However, the fetal PA oxygen response has been little studied, the identity of the DA oxygen sensor remains elusive, and the basis for the opposing …
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Enhancing the Performance of Pt(II)-Based Oxygen Sensing Probes by Expanding the Scope of N,C-Chelate and Ancillary Ligands.
… probes for the detection of molecular oxygen. By varying the N,C-chelates of the OSPs (oxygen sensing probes), it was determined that benzothiophene-pyridyl chelates have greater sensitivities compared to the benzofuran-pyridyl and pyridyl-indole chelates. By further altering the …
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Tuberculosis, Anaemia and Erythropoietin: a study evaluating the role of erythropoietin in the pathophysiology of the anaemia of tuberculosis
… order to characterize the mechanisms involved in oxygen sensing, the murine Epo gene was studied to define the sequences within the enhancer involved in oxygen sensing and Epo gene expression. To this end, transfection experiments of deleted, mutated and re-iterated enhancer sequences located 3' …
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Electrodeposition and Characterization of Copper Oxide Thin Films
… with applications in solar energy conversion and oxygen sensing devices. Fabrication of these films by electrodeposition offers a simple and cost effective method for producing large-area thin films in mass quantities. An interesting phenomenon associated with this material is the variation of the …
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A family of multi-functional phosphorescent bioprobes based on the PtPFPP scaffolding moiety
… cells and tissues. While phosphorescence-based oxygen sensing offers great potential for such investigations, current probes still show limitations in terms of their bio-distribution and analytical performance. New improved O2 probes are highly needed. In this project we synthesized a family of …
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Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2
… is tempered through HIF-1α hydroxylation by the oxygen-sensing prolyl hydroxylase-domain protein 2 (PHD2), and subsequent ubiquitination and degradation. Furthermore, we found that DAP5 regulates HIF-1α abundance and Akt signaling through DAP5:eIF2β-dependent translation of PHD2. …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… syndrome principally involves dysregulation of oxygen sensing pathways including the Hypoxia Inducible Factor (HIF)-Vascular Endothelial Growth Factor-A (VEGF-A) and HIF-Erythropoietin (EPO) pathways. RNA sequencing (RNA-Seq) data from our previously published experiments revealed a potentially …
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Studies of measurement techniques for indirect chemical sensing based on fluorescence spectroscopy and applications for fibre-optic sensors
… enabled optimised design of interrogators for sensing oxygen using a fluorescent polymer encapsulated ruthenium complex. Two basic interrogation methods were explored, using blue LED excitation.<br/>The Rapid Lifetime Detection (RLD) scheme, a fluorescence interrogation method based on direct …
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Gas-sensitive holographic sensors
… (λ). The present work reports the fabrication of oxygen and ammonia sensors in Nafi on membranes and hydrocarbon and volatile organic compound sensors in poly(dimethylsiloxane) (PDMS) films. A holographic recording technique was developed to suit these materials consisting of the in situ formation …
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