The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets

The design of an extruder-based continuous tablet forming process of a sample active pharmaceutical ingredient (API) and ethyl acetate requires a device to form and compress the tablets. The flow of the wet extrusion is driven by the pressure head generated by the torque of the screws; the minimum pressure head is dictated by the head loss across the exit die. Since the API powder blend and ethyl acetate solvent form a highly filled suspension paste, the liquid phase tends to flow at a different speed than the solid when the driving pressure changes. As such, the three die geometries, straight, curve, and elbow, resulted in average steady state liquid mass fraction of 0.179 ± 0.005, 0.249 + 0.01, and 0.200 ± 0.009 respectively, although the increases in mass fraction do not correspond to increases in pressure drop across the die. This experiment tests a particular tablet forming process, which involves using the pressure of the extruder to squeeze out the liquid content of the tablets during forming. The occurrence of liquid phase migration after this tabletting process is confirmed in each die tested. The extent of variation in liquid content shows a 30% increase for the straight die, a 50-200% increase for the curve die, and 50-150% increase for the elbow die. These results suggest that a tablet forming device should not use the pressure of the extruder, due to the complications of paste flow.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2011

Author dc:creator

• Nagaraj, Aditi

Advisor dc:contributor.advisor

• Jung-Hoon Chun.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/68850

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/68850