Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Tabletting"”.
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Condition monitoring of pharmaceutical powder compression during tabletting using acoustic emission
… the complex physical changes which occur during tabletting. Capping and lamination are serious problems that are encountered during tabletting. A capped or laminated tablet is one which no longer retains its mechanical integrity and exhibit low strength characteristics. Capping and lamination can …
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Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as an anti-retroviral for the treatment of human immunodeficiency virus (HIV) type I. It is classified as a class IΙ drug under the Biopharmaceutical Classification System (BCS) and exhibits a low solubility (aqueous solubility of …
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Engineering of composite pharmaceuticals with improved physicochemical and mechanical properties
Tabletting by direct compression (DC) is the preferred method of tabletting as compared to granulation techniques because among other benefits it is simple, quick, and cost-effective. However, most pharmaceutical powders are not compressible via DC due to poor flowability, compactibility, …
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The effect of speed of compression on the properties of compacts.
… time profiles seen on any production tabletting machine. The system has been validated to monitor punch displacements to ?12pm and loads to ?O.05% of full scale. Confidence in the results obtained using the Simulator were enhanced by comparison with other operational Simulators. The …
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Pharmaceutical formulation development utilizing hot melt extrusion and other techniques for development of immediate and controlled release dosage forms
… to the component systems which find utility in tabletting applications. Extruded matrices were compressed into tablets and tabletability profiles generated. Simultaneously tablet hardness evaluation was performed using conventional characterization techniques as well as using a texture analyzer. …
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The role of moisture profiling towards understanding pharmaceutical solid state functionality. Validation and the application of a moisture profiling analytical tool for investigation into the characterisation of and prediction of the effects of compaction and storage on different lactose physical forms
… supplementary analysis. Secondly the effects of tabletting were explored, different compaction forces were investigated to observe if this had any notable effects on equilibrium relative humidity of the different lactose forms. Finally subsequent storage of the compacts were examined in order to …
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The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets
… occurrence of liquid phase migration after this tabletting process is confirmed in each die tested. The extent of variation in liquid content shows a 30% increase for the straight die, a 50-200% increase for the curve die, and 50-150% increase for the elbow die. These results suggest that a …
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Formulation and evaluation of diclofenac sodium dispersible tablets
… concentrations of 2% and 5% of the tablet mass. Tabletting was performed using a Cadmach® (India) single-punch tabletting machine. The four formulations were put on accelerated stability according to ICH guidelines for three months at 25°C/60%RH, 30°C/65%RH and 40°C/75%RH. HPLC was used to …
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Low Frequency Dielectric Investigations on Hydrated Pharmaceutical Powders
… of two pharmaceutical technologies, viz. tabletting (including granulation) and the lyophilisation of proteins. A previously poorly characterised low frequency dispersion in MCC is shown to be a bulk process (a separate dispersion due to the presence of the blocking electrodes was …
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Exploring new applications for photophysically encoded microcarriers
… produced by granulation did not deform during tabletting and that the code in the beads remained readable. We also found evidence that, after oral intake, the encoded microparticles are highly unlikely toxic to humans.
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Ultrasound Assisted Processing of Solid State Pharmaceuticals. The application of ultrasonic energy in novel solid state pharmaceutical applications, including solvent free co-crystallisation (SFCC) and enhanced compressibility
… drugs without the need to use a conventional tabletting machine.
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COMPRESSION AND MOISTURE EFFECTS ON THE STABILITY OF DRY VITAMIN A ACETATE IN COMPRESSED TABLETS
… relationship between ompression force during tabletting and also any additional effect that may be contributed dur—ing slugging. To evaluate the resistance of the gelatin beadlets to the des-tructive forces existing during tablet compression a number of dif-ferent tests were employed. Dry …
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Application of raman spectroscopy in pharmaceuticals
… of APAP which is highly desired for its unique tabletting properties which are important for pharmaceutical manufacturing. Stabilization of metastable type II APAP was achieved by micronizing or nanocoating stable monoclinic crystallites of type I APAP. In addition, as an Appendix to the thesis, …
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Particle engineering via surface modification during micronization for pharmaceutical applications
… API micronization, without any adverse impact on tabletting operations and tablet properties. Next, an in-depth understanding of the effect of milling and dry coating on the surface properties of milled ibuprofen powders was investigated. Inverse Gas Chromatography technique was used and the …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and carrageenan gums as well as hydroxypropyl methylcellulose (HPMC) were …
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Preparation and applications in confectionery of co-crystalline sugar products and a novel hydrated form of sucrose
… 90% of glucose respectively. They showed good tabletting properties even without the use of binding agent. The tablets prepared had a crushing strength similar to superior to those prepared with a granulated powder. They also showed good flavour retention.
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A novel solvent-free high shear technology for the preparation of pharmaceutical cocrystals
High shear melt granulation (HSMG) is an established technology for a production of densified granules. In this project, it was used as a novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to …