Fabrication of drug delivery MEMS devices

There is considerable amount of interest in the immediate treatment of personnel involved in high risk situations on the battlefield. A novel approach to drug delivery on the battlefield based on MEMS technology is discussed. By combining three separately fabricated layers, a single implantable drug delivery device capable of delivering up to 100 mm3 of a vasopressin solution was developed. In vitro release of vasopressin was observed and the I-V response of the bubble generator was characterized. Results show that the voltage at the time of release is ~11V while the current is ~0.35A, giving a power output of 3.79W. The time to total release of the drug was less than 2 minutes.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Lei, Wang S

Advisor dc:contributor.advisor

• Michael J. Cima.

• Materials Science and Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/58271

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/58271