Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1388 for “"Drug Delivery"”.
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Single Subcompartment Drug Delivery
Most drugs are administered systemically, intravenously or orally, but there are inherent challenges with these methods. Drug distributes throughout the body, which results in two main challenges: (1) poor efficacy due to the under accumulation of drug at sites of disease and (2) side effects due …
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Magnetic Targeted Drug Delivery
… guidance system that is needed for an effective drug delivery system. This thesis reviews past magnetic drug delivery work, variables, and concepts that needed to be understood for the development of an in vivo magnetic drug delivery system. The results of this thesis are the concise study and …
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Phonophoresis and topical drug delivery
… gel. The application of heat alone increased drug migration by a similar magnitude as the ultrasound, indicating that ultrasonic heating directly increases the thermodynamic potential for diffusion. In the second experimental system, whole rat skin was pre-sonicated and then examined for …
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Targeted drug delivery within the eye
… segment of the eye using microneedles as a drug delivery platform. The first part of the work determines the ability to deliver protein therapeutics into the cornea using coated microneedles to suppress corneal neovascularization in a rabbit model. The data show that highly targeted delivery …
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Polymer Electrolytes For lontophoretic Drug Delivery
… novel in providing an external stimulus to ionic drugs in their passage across a skin. Hence, a positively charged drug may be delivered across the skin, by placing it under the positive electrode where it is repelled and attracted toward a negative electrode positioned elsewhere on the body. For …
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Nanostructured materials for hydrophobic drug delivery
… several properties that make them promising for drug delivery applications. In this work, Î2-carotene (BC) and clofazimine (CFZ) are used as model molecules to investigate the physical and chemical processes governing the interactions of hydrophobic molecules with both inorganic (Psi) and …
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Silver Nanoparticles As Drug Delivery Systems
… site. Here, we test a SNP based osteogenic drug delivery system, both in vitro and in vivo, that will provide clinicians and health care providers control of the activation stem cell differentiation leading to the formation of bone. We will evaluate the in vitro osteogenic differentiation of …
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Proniosome formulations for pulmonary drug delivery
… dipropionate (BDP, 5 mole %) as a model drug. When niosomes were processed via probe sonication, photon correlation spectroscopy study showed that niosomes generated from proniosomes had larger size than conventional niosomes, being 202 nm and 160 nm, respectively. Transmission electron …
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Biodegradable polyanhydrides as drug delivery systems
… are useful biodegradable vehicles for controlled drug delivery. In aqueous media the breaking of the anhydride bonds resulting in gradually polymer fragments collapse and release drugs in a controlled manner. In this study, two new biodegradable polyanhydrides copolymers were synthesised using a …
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Microneedle gastric retention for drug delivery
Traditional drug delivery methods, such as injection and ingestion, are associated with many challenges, including patient needle-phobia and patient adherence to a medication regimen. Biologic molecules, in particular, must be injected due to degradation by enzymes in the GI tract. Previous …
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Fabrication of drug delivery MEMS devices
… on the battlefield. A novel approach to drug delivery on the battlefield based on MEMS technology is discussed. By combining three separately fabricated layers, a single implantable drug delivery device capable of delivering up to 100 mm3 of a vasopressin solution was developed. In vitro …
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Drug delivery device for bladder disorders
… requires repeated instillations due to rapid drug voiding by urination, and the frequent urinary catheterizations involve risk of urinary infection and patient discomfort. An alternative, site-specific local delivery approach was created using a reservoir-based drug delivery device. This novel …
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Microneedles for Drug Delivery in Aquaculture
… be applied in situ and dissolve to release the drug. The focus of this project is the needle fabrication method and coating selection to provide necessary mechanical strength to withstand aquatic environments. It was found that hollow, silk microneedles coated in shellac/ethanol coatings of …
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Synthetic Degradable Polymer Systems for Drug Delivery
Drug delivery technologies can play a crucial role in enhancing treatment outcomes by improving therapeutic efficacy, reducing toxicity, and increasing patient compliance. Osteoarthritis (OA) is a degenerative disease that affects all joint tissues, leading to pain and loss of mobility, with no …
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Drug delivery strategies to overcome ocular hypertension
… limitations, this thesis explores two innovative drug delivery strategies using anti-glaucoma drug-rich nanoparticles, called colloidal drug aggregates (CDAs). The first strategy involves a periocular hydrogel-nanoparticle composite designed for sustained, local delivery to the eye. Timolol …
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… that are being investigated for ocular drug and gene delivery. Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable drugs and allows potentially favorable ocular biodistribution. This work …
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Novel polymeric microcapsules for targeted drug delivery
… investigated how to develop a post-ruminal delivery system based on polymeric microencapsulation. A major criterion was to develop microcapsules with reversible switching in response to changes of pH in the in vivo environment so contents could be released. The microcapsules must have a thin …
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