A fully implantable intracochlear drug delivery device : development and characterization

In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of sensorineural hearing loss. This versatile device is envisioned to deliver multiple therapies and control the sequence and rate of drug dosing. Such a system could have an immediate application in the treatment of ototoxic and inflammatory conditions affecting the inner ear, including autoimmune inner ear disease and cisplatin-induced ototoxicity. Current efforts include ongoing refinement of the design, miniaturization of components, and testing in an in vivo guinea pig model. This thesis focuses on the interactions between the device and inner ear, including the investigation of drug transport due to convective diffusion in the cochlea during drug delivery. A lumped-parameter model was implemented in an electrical circuit simulator after converting mechanical variables to their electrical analogues. A flow module described the output of the microfluidic system and used storage and loss elements to represent cochlear anatomy contributing to the flow profile. In the other portion of the model, a transport module solved for the drug concentration profile within the cochlea resulting from diffusion and convection. The model was validated using a bench-top fluorescent flow study and was compared to in vivo animal drug delivery studies. Additionally, mechanical and biological interactions related to protein and tissue biofouling were investigated.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2009

Author dc:creator

• Swan, Erin Eileen Leary, 1976-

Advisor dc:contributor.advisor

• Roger D. Kamm.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/55258

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/55258