Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Pig model"”.
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A guinea pig model of human respiratory syncytial virus lung infection
… airway inflammation underlying asthma, a guinea pig model of human RSV lung infection was developed to test the hypothesis that RSV persists within the lung following resolution of acute bronchiolitis. One month old, "juvenile" guinea pigs, intranasally inoculated with human RSV, were compared on …
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Exploring the utility of the pig model for predicting bioavailability in humans
… considerable debate on which preclinical animal model is most appropriate for assessing oral bioavailability in humans. In order to streamline preclinical development, and reduce repeated testing in various animal models, it is necessary to get a better understanding which particular animal model …
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Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
… and mortality around the world. Gnotobiotic (Gn) pigs are the ideal large-animal model that allows for accurate, and precise, preclinical evaluation of vaccine efficacy. Similarities in gastrointestinal anatomy, physiology, and immune system allows for direct translation of results from Gn pigs to …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
… the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available for this animal are limited. Consequently, many reagents and assays used must be developed and optimized in lab. We utilized several different hybidoma …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
… the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available for this animal are limited. Consequently, many reagents and assays used must be developed and optimized in lab. We utilized several different hybidoma …
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Inclusion of Olive or Coconut Oil in a High-Fructose High-Fat Diet Increases Liver Injury in a Pig Model of Pediatric NAFLD
… of NAFLD. Thirty-eight 15-d-old Iberian pigs housed in pens balanced for weight and sex were randomly assigned to receive 1 of 3 hypercaloric high-fructose high-fat (HFF) diets for 10 weeks: 1) lard (LAR; n=5 pens), 2) lard + olive oil (OLI, n=10), and 3) lard + coconut oil (COC; n=10). …
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Are gadolinium contrast media really less nephrotoxic than iodine agents in radiographic examinations? A comparison in relation to their ability to attenuate x-rays in a pig model
… 3 ml of each test solution were injected in 8 pigs/study at a rate of 20 mL/min into the balloon-occluded (10-minutes) right renal artery of left-sided nephrectomized pigs. Test solutions: 1) 0.5M gadopentetate (1.96 Osm/kg H2O), 0.5M gadodiamide (0.78 Osm/kg), 0.5M iohexol (190 mg I/mL; 0.42 …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… vaccines are needed. The gnotobiotic (Gn) pig model of HRV infection and diarrhea has long been used in the evaluation of novel HRV vaccines due to Gn pigs' susceptibility to HRV infection, development of clinical signs, histopathological changes in the intestine, and the infection kinetics …
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Short-Chain Fatty Acids and Functional Adaptations in the Neonatal Intestine
… to enhance this adaptive process in adult animal models, and data from our lab indicates that butyrate (Bu) results in marked changes in glucose transport in the intestine within minutes. We hypothesized that SCFA and Bu would enhance glucose transport and transporter gene expression in a neonatal …
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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions
… as an ideal means of antigen display. This model antigen display system was capable of assembling into multivalent, highly repetitive structures thereby displaying many copies of the attached epitope in the assembled virion. Three TMV-based vectors were acquired, which were essentially …
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Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
… and treatment strategies. Gnotobiotic (Gn) pigs are an attractive animal model for studying enteric viruses due to their similarities to humans, particularly in regards to the immune system and gastrointestinal anatomy and physiology. Here, to establish a reliable Gn pig model of human …
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Pathogenesis, immunity, and prevention of human norovirus infection in gnotobiotic pigs
… cell culture system and a suitable small animal model, while gnotobiotic (Gn) pigs have been a unique animal model for understanding HuNoV pathogenesis and immunity, as well as evaluating vaccine and therapeutics. Recent reports of HuNoVs infection and replication in B cells supplemented with …
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Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart
… infarction, delivered using an AAV vector in a pig model of ischemia-reperfusion and as a synthetic RNA molecule after a single intracardiac injection in mice. Methods and Results: We evaluated the efficacy of miR-199a in a pig model of ischemiareperfusion after direct myocardial injection of an …
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A study of the effects of sucralfate in the bile duct litigated pig peptic ulcer model with particular reference to the effects on the physico-chemical properties of gastric mucus and including comparisons with famotidine and misoprostol
… of in vitro work on the effects of Sucralfate on pig gastric mucus, claimed that Sucralfate acted by altering the physico-chemical properties of mucus to increase the viscosity and retard the back diffusion of H+ ions. The work described in this dissertation set out to verify, in vivo, these …
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A fully implantable intracochlear drug delivery device : development and characterization
… of components, and testing in an in vivo guinea pig model. This thesis focuses on the interactions between the device and inner ear, including the investigation of drug transport due to convective diffusion in the cochlea during drug delivery. A lumped-parameter model was implemented in an …
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Dietary Fat and Sugar Induce Obesity and Impair Glucose Tolerance in Prepubertal Pigs
A pig model of childhood obesity was used to study the effects of dietary energy on body adiposity, and blood parameters associated with impaired glucose clearance. Prepubertal female pigs weaned at 21 d of age were fed control (CON), refined sugar (SUG), fat (FAT), and sugar-fat (SUGFAT) diets in …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… Rom LP. When characterized in the in vivo guinea pig model, the CanZ/RomLP mismatch resulted in attenuation of the virus and a pathology profile similar to rCan. In addition, it was narrowed down to a single mutation (V64G) within the Z that conferred the attenuation when paired with Rom LP. The …
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Assessment of early-life choline and iron deficiencies on neurodevelopment in the young pig
… dietary intake remains a problem worldwide. The pig has emerged as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. The use of magnetic resonance imaging allows for a non-invasive understanding of how nutrition affects neurodevelopmental …
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Development of an Ingestible Fluid Wicking Gastric Electrical Stimulation Platform for Hormone Modulation
… ghrelin, a hormone associated with hunger, in a pig model. Next, we translate this stimulation approach into a non-invasive capsule system that is then optimized through rapid iteration enabled by 3D printing and an in vitro system replicating the stomach’s mechanical and electrical properties. …
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