Formulation of oral dosage forms by three dimensional printing

Pharmaceutical grade materials were used in the fabrication of fast-release and extended-release oral dosage forms. Tablets were processed by employing a method of solid freeform fabrication known as three dimensional printingTM (3DPTM). A microcrystalline cellulose powder was used in combination with pH-dependent and permeable polymeric binder solutions. Release studies in acidic media were performed using both dye and drug (antihistamine) as actives. Deposition was performed by micro pipette into concept devices. It was concluded that printing parameters could be used to control the microstructure and release behavior. The performance of a drop-on-demand inkjet printing system was evaluated to be highly accurate, and the system was used in the fabrication of model oral dosage forms. Tablets were constructed with a permeable polymer as binder. Mechanical tests showed that the tablets were comparable to industry references for both strength and friability. A USP dissolution method involving an acid and buffer stage was used for extended-release studies. Release by diffusion was found to depend on device porosity level and drug distribution as defined during fabrication.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

1998

Author dc:creator

• Palazzolo, Robert D. (Robert David), 1973-

Advisor dc:contributor.advisor

• Michael J. Cima.

• Materials Science and Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/50617

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/50617