Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"extended release"”.
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… these drawbacks, this study aimed to develop an extended-release thermosensitive hydrogel formulation that was applicable to the injectable administration. The praziquantel-loaded hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications of …
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Developing polypyrrole coated coronary stents for extended release of Sirolimus
… The most critical limitations are poor drug release profiles, hypersenisvity reactions and delayed endothelium healing which can lead to fatal thrombotic events. Therefore there is a need to develop a more effective DES. The aim of this work was to develop a novel DES coating with an improved …
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and pressed into a ribbon like compact. The compact is thereafter milled to obtain …
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The effects of extended-release eprinomectin on heifer performance and fescue toxicity and an evaluation of parasite resistance
… over time. As new versions of anthelmintics are released to the market, evaluations for resistance need to be conducted. In addition, the use of anthelmintics has also been reported to be beneficial at reducing negative impacts of fescue toxicity. Previous work has shown improvements in growth …
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The pharmacokinetics of single oral dose extended-release topiramate and adverse effects after multi-dose administration in healthy cats
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Induction of transdermal buprenorphine (Butrans®) to extended-release buprenorphine subcutaneous injection (Sublocade®) for opioid use disorder: a case series & a qualitative study on the experiences, barriers, and understanding of opioid agonist treatment among youth with opioid use disorder in Vancouver, British Columbia
… using transdermal buprenorphine (Butrans)®, to extended-release buprenorphine subcutaneous injection (Sublocade®) for the treatment of opioid use disorder, done over a 48-hour period. Both patients experienced minimal withdrawal symptoms throughout induction and no adverse effects. This …
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An evaluation and comparison of current FDA-approved treatments for obesity
… liraglutide, lorcaserin, naltrexone/bupropion extended-release, and phentermine/ topiramate extended-release became FDA-approved for long-term treatment of obesity. Each drug acts on a specific part of the CNS to modulate appetite and cause decreased food intake in patients. Clinical trials …
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Formulation of oral dosage forms by three dimensional printing
… materials were used in the fabrication of fast-release and extended-release oral dosage forms. Tablets were processed by employing a method of solid freeform fabrication known as three dimensional printingTM (3DPTM). A microcrystalline cellulose powder was used in combination with pH-dependent …
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The disposition and bioequivalence of single-dose compounded, commercial, and intravenous levetiracetam in healthy dogs
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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A Nationwide Study of ADHD Drug Use among Adults in Iceland 2003-2012
… increased 3-fold, similarly among men and women. Extended release methylphenidate formulations were the most commonly used ADHD drugs. Specialists in psychiatry initiated treatment in 79% of new adult ADHD drug users. The proportion of users still receiving treatment after one year varied from …
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Fabrication of complex oral drug delivery forms by Three Dimensional Printing (tm)
… forms were fabricated with 3DP to show lagged-release, extended-release, double-release, and zero-order-release. Release properties, such as lag time and release rate, were manipulated by varying the printing parameters.
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
… recrystallization prevention and pH-triggered release due to the free -COOH groups. Rifampicin (Rif), Ritonavir (Rit), Efavirenz (Efa), Etravirine (Etra) and Quercetin (Que) cellulose ester ASDs were investigated in order to increase drug solubility, prevent release at low pH and controlled …
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The effects of niacin and a single bout of exercise on blood lipid and lipoprotein profiles in postmenopausal women
… condition consisted of ingesting 1,000 mg/day of extended-release niacin for 4 weeks. Rest (R) and exercise (E) trials were randomly assigned within each WON or WN condition. During the E trial treadmill exercise was performed at 60% HRR until 400 kcal were expended. Fasting blood samples were …
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Self-assembled peptide as a long-acting drug formulation
… to soluble peptides, and allow a controlled release by dissociation of monomers from the fibril termini [5]. Here I propose self-assembled peptides as a prolonged-activity, self-mediated drug delivery system for subcutaneous injection of pharmaceutically active drugs. Oxyntomodulin is used as …
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Investigating the Receptor Interactions and Mechanisms of a Folic Acid-Conjugated Nanoparticle in the Treatment of Breast Cancer
… stimuli-responsive, active targeting, and extended-release of hydrophobic chemotherapeutic agents. We have demonstrated that this NP effectively penetrates the inner core of 3-dimensional cancer spheroid models to deliver anti-cancer agents. Interestingly, NPs not loaded with …
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Performance-Based Quality Specifications: The Link between Product Development and Clinical Outcomes
… risk of inefficacy and toxicity for dosing of extended-release theophylline tablets. Sensitivity analyses revealed that patient compliance and content uniformity significantly influenced the probability of observing an adverse event.</p><p> The Monte Carlo risk assessment platform defined the …
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The Role of Phase Inversion in the Drug Release Kinetics of Injectable Polymer Solutions
… induced phase inversion plays in the protein release kinetics of injectable drug delivery devices are presented. In situ optical techniques coupled with scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC) were used to examine the relationship between the phase …
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Inorganic nanoparticles for applications in biomedical sciences
… better bioavailability, targeted delivery and extended release of drugs. In this work, we demonstrated the formulation and methods of use for three different nanocarriers. 1) 166Ho iron garnet nanoparticle-containing bandages for treatment of squamous cell carcinoma of skin: Squamous cell …
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Degradable Polymers for the Controlled Delivery of Bioactive Small Molecules
… (HNO). This dissertation covers compounds that release HNO, which possesses similar functions to NO (cardioprotection and vasodilation) but has been studied much less. While HNO, H2S, and RSSH have vital biological functions, they also have short half-lives in vivo (seconds to minutes), thus …
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