Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito

During development of an adult organism from a fertilized embryo, signaling pathways are deployed reiteratively to regulate a variety of cellular processes, including cell proliferation, specification, differentiation, migration, survival and death. These signaling pathways do not act independently, but rather are integrated to yield desired developmental outcomes. While there are a variety of mechanisms by which signaling pathways are integrated, our work has focused on signal integration at the level of transcriptional control. Signaling pathways have been demonstrated to converge at the level of transcription, either by regulating activity of a common transcription factor and affecting its transcriptional output, or by regulating activity of distinct transcription factors, which target a common set of genes. In order to understand how signaling pathways are integrated to affect developmental outcomes, it is not only necessary to investigate the regulation of these transcription factors during development, but also it is necessary to identify their downstream transcriptional targets. In this thesis we have focused on the roles of two downstream transcriptional effectors, Eyes absent (EYA) and Spenito (NITO), in Drosophila eye development.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Biology.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Jemc, Jennifer Colleen

Advisor dc:contributor.advisor

• Ilaria Rebay.

• Biology.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/38996

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/38996