Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Eye development"”.
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Characterization of split ends function during Drosophila eye development
… pathways coordinate all aspects of metazoan development, including cell fate specification, differentiation, and growth. Rather than functioning as completely independent modules, signaling pathways interface to create a web of specific interactions that a cell integrates in a spatial and …
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Identification of echinus and characterization of its role in Drosophila eye development
The precise structure of the adult Drosophila eye results from a coordinated process of cell sorting, differentiation and selective cell death in the retinal epithelium. Mutations in the gene echinus cause supernumerary pigment cells due to insufficient cell death. This study reports the …
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Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development
… is essential for many aspects of normal animal development. However, little is known about how cell motility and associated changes in cell shape are regulated in the context of epithelial tissue patterning. This study investigates the cell motility of developing ommatidia, a process known as …
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Mechanisms of p19Arf-Mediated Regulation of Perivascular Cell Biology During Mammalian Eye Development
… essential function for p19Arf during mammalian eye development. In this context, p19Arf is required for the ultimate involution of the hyaloid vasculature system that exists in the primary vitreous space and serves to nourish the lens and retina. Knock-out mouse models for p19Arf demonstrate …
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Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito
During development of an adult organism from a fertilized embryo, signaling pathways are deployed reiteratively to regulate a variety of cellular processes, including cell proliferation, specification, differentiation, migration, survival and death. These signaling pathways do not act …
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Genetic Control of Eye Development, a Case Study Focused on the Murine Mutation Belly Spot and Tail (BST)
<p>Development of the eye is controlled by a network of genes, often conserved, that regulate the timing and location of cellular differentiation. One approach to understanding this network of genes and their interaction is to focus on mutations, spontaneous or induced, that predictably disrupt the …
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Isolation and Characterization of a Novel Gene, xMADML, Involved in Xenopus Laevis Eye Development Using Cornea -Lens Regeneration
… cascades necessary to control retina and lens development. Further understanding of the genetic controls of eye development will allow for increased understanding of the general process of development.
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Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
<p>Diseases of the posterior segment of the eye such as diabetic retinopathy, age related macular degeneration and glaucoma are the leading causes for blindness throughout the world. Topical eye drops is the most convenient formulation for daily application. The human eye, however, presents major …
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A Phenotypic And Genetic Characterization Of The Cell Adhesion Molecules Echinoid And Friend-Of-Echinoid In The Directed Cell Movements Of Ommatidial Rotation During Drosophila Eye Development.
Correct development of multicellular organisms relies on the precise patterning of cells, which must respond to and interpret specific cues that instruct the cells to differentiate and often undergo directed cell movements and rearrangements to give rise to functional tissues and organs. …
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Investigating the role of gene duplication in the evolution and divergence of Arachnids
… the role of Wnt signalling during spider eye development and the expression patterns of Pax6 and atonal duplicates in the developing head of P. tepidariorum. My results further support the role of Pt-Sox21b-1 as a gap gene in spider segmentation, and conserved roles for Wnt signalling and …
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Role of Xenopus Pitx3 during early development.
… identified which expresses in the midbrain and eye. The main focus of this study was to elucidate the role of Xenopus Pitx3 during eye development. As a side project, we also studied the role of this gene in the left-right patterning and axis formation in Xenopus. Here, we report the cloning of …
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The role of spectrin in Drosophila photoreceptor development.
… effects of spectrin on Drosophila photoreceptor development. In fruit flies the mosaic technique can be used to express both the mutant and the wild-type tissue in a single eye. The mosaic eyes were dissected, fixed, and mounted onto a slide and analyzed using confocal microscopy. Specific roles …
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The Effects of Benzyl Alcohol on Developing Zebrafish (Danio rerio)
… We designed a series of experiments to study the developmental effects of benzyl alcohol exposure on zebrafish (Danio rerio), a well-established model for development. Zebrafish were exposed starting at high blastula stage of development (4 hours post-fertilization, hpf) and finishing at free …
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Asymmetric localization of prospero and numb specifies cell fates in the Drosophila CNS
A central question in developmental biology is how can two genetically equivalent cells become different? Nowhere is this question more compelling than in the case of sibling cells, where each is derived from the single division of a parental cell. This thesis identifies two proteins involved in …
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Role of Drosophila Rap/Fzr (Cdh1) in retinal axon targeting and its interactions with Loco, Liprin-a and Ras
The development of the wild type Drosophila compound eye involves stereotypical targeting of photoreceptor axons to the specific layers of the optic ganglion, medulla and lamina, in the third instar larvae. To test the hypothesis that ubiquitin ligases play an important role during retinal axon …
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Functional studies of <i>Ci-Gsx</i> gene in the developing central nervous system of <i>Ciona intestinalis</i>
… and molecular similarities to vertebrate eye, thus representing a valuable tool to study the basic mechanisms of eye development. The aim of my PhD work has been the investigation of Ci-gsx function in the early specification of photoreceptor cells in Ciona intestinalis. To this end, I …
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Elucidating The Role of Rumi and O-Glucosylation In The Drosophila Eye
… protein Crumbs and the secreted protein Eyes shut (Eys). Both of these proteins are required for proper eye development and mutations in their human homologs cause a blindness disorder named retinitis pigmentosa. Therefore, we sought to determine whether Rumi plays a role in photoreceptor …
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Study of the role of miR-204 in photoreceptor development
… role of specific miRNAs in regulating the retina development especially photoreceptors. In particular, I focused on miR-204, one of the miRNAs our laboratory is mostly focusing on, and whose role in multiple aspects of eye development has been elucidated in the past few years from our lab and …
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The Identification of the Mid Transcription Factor Regulatory Network Specifying Cell Fate and Regulating Survival in the <i>Drosophila</i> Eye
… express in a wide range of developing mammalian eye tissues including those of the human fetus, the function of this transcription factor is unknown in the development of eye tissue. This current study is the first attempt to show that Mid and its para log H15 are expressed within distinct …
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