Design of an endoscopic biopsy needle with flexural members

As a minimally invasive means of extracting a tissue sample from a patient, current endoscopic biopsy needles generally do not preserve tissue histology and often require multiple attempts to obtain a tissue sample. This paper presents an endoscopic biopsy needle with internal flexures that enable tissue to enter the hollow needle and then be severed from surrounding tissue when the needle is withdrawn. Using force-deflection and sample weight data from 10x scaled prototypes, variations of a flexural design captured 1.1 grams of a tissue phantom on average, as compared to wedge-type designs that averaged of 0.7-0.8 grams. Peak entrance forces for the flexure design were lower than for both wedge and extended wedge designs, and resistance forces were higher upon needle extraction. A low-angle 15-degree feature produced lower entrance resistance and larger exit resistance compared with 30 degree, 45 degree, and 60 degree features, which is desirable when retaining tissue. Manufacturing of a 1x scale prototypes, using a grinding and laser cutting process, suggested that flexural features could be produced in current endoscopic biopsy needles, but changes to the beveled cutting tip would first have to be made before flexural elements could be tested on actual liver samples.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2006

Author dc:creator

• Figueredo, Stacy L. (Stacy Lee), 1981-

Advisor dc:contributor.advisor

• Alexander H. Slocum.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/38273

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/38273