Spinal cord regression via collagen entubulation

(cont.) days) post-implantation. Histological and immunohistochemical analyses showed severe fibrous and glial scar formation in Groups I and III, less fibrous scarring in Group II and very little scar manifesting in Groups IV and V. A quantitative analysis of myelinated axons in the center of the explants corresponded with the assessment of scar as a physical barrier to competent axon growth. Groups I and III exhibited the least regenerated axons, Groups IV and V the most. The findings also validated the effectiveness of the dorsal barrier in promoting spinal cord regeneration. Overall, the combination of wrap membrane and dorsal barrier (Group V) proved most effective in creating a hospitable environment for regenerative success.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Aeronautics and Astronautics.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2004

Author dc:creator

• Matin, Sajjad S. (Sajjad Shaikh), 1979-

Advisor dc:contributor.advisor

• Myron Spector.

• Aeronautics and Astronautics.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/28889

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/28889