Network tools forthe analysis and prediction of protein-protein interactions

In this thesis, we present two computational platforms for future biological research. The first, FNAC, is a flexible programmatic Framework for Network Analysis and Comparison that simplifies many common operations on biological networks. As a demonstration of FNAC, we investigate the properties of several prominent protein function and protein-protein interaction networks. In doing so, we uncover evidence suggesting that a recently-developed technique for annotating proteins may also have substantial value in the computational prediction of protein-protein interactions. Our second computational platform, the Coiled-Coil Database (CCDB), serves as a central and easily queryable repository for information about the coiled coil protein structural motif in a variety of organisms.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2004

Author dc:creator

• Weston, Kevin T. (Kevin Thomas), 1981-

Advisor dc:contributor.advisor

• Amy E. Keating.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/17999

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/17999