Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"computational platform"”.
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In silico vaccine design for hepatitis C: A computational platform for fighting disease
… and rationally design vaccine immunogens. This computational design protocol will guide and accelerate vaccine development efforts by massively reducing the need for expensive and laborious trial-and-error experimentation. While this work has focused on HCV, the grander picture is that the tools …
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Integrated probabilistic risk assessment (I-PRA) methodology and computational platform for fire PRA of nuclear power plants
… risk scenarios in classical PRA; b. Integrates a Computational Fluid Dynamics (CFD)-based fire model, the Fire Dynamics Simulator (FDS), with classical PRA through a probabilistic interface that is equipped with uncertainty quantification, dependency modeling, and Bayesian updating. To alleviate …
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Development of an efficient finite volume computational platform for the simulation of complex flows of complex fluids governed by the Rolie-Poly model
… of an efficient finite volume computation platform for complex flows governed by the Rolie-Poly constitutive equation has been presented in this thesis. The test cases of the lid-driven cavity flow and the planar 4:1 contraction flow were used to validate the solver which was used with the …
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Computational verification of published human mutations
… dynamics. This thesis covers the assembly of a computational platform for verifying these variations, based on accurate, published, experimental data.
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Network tools forthe analysis and prediction of protein-protein interactions
In this thesis, we present two computational platforms for future biological research. The first, FNAC, is a flexible programmatic Framework for Network Analysis and Comparison that simplifies many common operations on biological networks. As a demonstration of FNAC, we investigate the properties …
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Modelagem dos processos físico-químicos e atmosféricos envolvidos na formação de oxidantes fotoquímicos em megacidades: o caso da região metropolitana do Rio de Janeiro
Presents an integrated computational system composed of a meteorological model, biogenic / anthropogenic emissions and air quality, implemented and adequate in a high performance computational platform, for the understanding of dynamic, thermodynamic and physico-chemical processes that impact on …
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COMPUTATIONAL MODELING OF BACTERIAL OUTER MEMBRANES AND DEVELOPMENT OF HIGH-THROUGHPUT SCREENING PLATFORM FOR ANTIBIOTICS
… outer membrane models and the OMPs to build a computational screening platform to quantify the transport properties of molecules across a bacterial outer membrane. The goal of the computational platform is to provide high-throughput screening of vast libraries of small molecules that have the …
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Micromechanical modeling of concrete at early age
… zone properties on concrete creep. An effective computational platform was developed to evaluate operator expressions in order to obtain relaxation and creep functions numerically. Through numerical examples, it is shown that triaxial generalization of Bažant’s solidification model enables robust …
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Dynamics and optimal control of information transmission in complex systems
The objective of this dissertation is to develop computational tools for studying the way processes of information spreading in a complex system are related to the organization of interactions among the constituents of the system. We are interested in understanding how topology and sequencing of …
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Methodologies to strategize the utilization of modeling and simulation for probabilistic risk assessment (PRA) of nuclear power plants: Applications in fire PRA
… extraction efforts. This thesis also develops a computational platform equipped with the PNP decomposition to facilitate the fire PRA of NPPs. The feasibility of the PNP decomposition methodology and the computational platform are demonstrated through a multi-compartment fire case study at an …
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Hydrodynamics of swimming microorganisms in complex fluids
… In this study, we use several different computational models to investigate the behavior of microswimmers.</p> <p>Microorganisms typically swim in the low Reynolds number regime, where inertia is negligible. They interact with each other, surfaces and external flow field. Microorganisms …
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Distributional Fingerprinting of Cell Population Phenotypes and Drug Activities
… condition. I established and characterized a computational platform using stochastic modeling of the Myc/Rb/E2F network that supports the analysis of distributional data—how it changes as a function of perturbation and how it can be used to infer cellular or external variables of interest. I …
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A Genetic Algorithm-Based Place-and-Route Compiler For A Run-time Reconfigurable Computing System
… is a technology which attempts to increase computational power by customizing the computational platform to the specific problem at hand. An experimental computing model known as wormhole run-time reconfiguration allows for partial reconfiguration and is highly scalable. In this approach, …
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Quality and Utility - On the Use of Time-Value Functions to Integrate Quality and Timeliness Flexible Aspects in a Dynamic Real-Time Scheduling Environment
… of which an application is made up and the computational platform on which it is to be executed. Many real-time scheduling algorithms base their decisions solely or partly on timing constraints expressed by deadlines which must be met even under worst-case conditions. The increasing …
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Development of Computational Antibiotic Screening Platform Across Bacterial Outer Membrane Proteins
… in vivo. With the aid of state-of-the-art computational methods and tools, we developed a computational platform to automate and study the translocation of small molecule drugs across bacterial outer membrane proteins, with a goal of accelerating the antibiotic discovery process. We applied …
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Image Segmentation, Parametric Study, and Supervised Surrogate Modeling of Image-based Computational Fluid Dynamics
… computation and imaging technology, Image-based computational fluid dynamics (ICFD) has emerged as a great non-invasive capability to study biomedical flows. These modern technologies increase the potential of computation-aided diagnostics and therapeutics in a patient-specific environment. I …
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Finite Element Modelling and Experimental Characterisation of Auricle Mechanics for Earable Design
… “earables” are emerging as a promising platform for neural interfaces, leveraging the ear’s anatomical accessibility, social acceptability, and structural stability. The auricle provides a natural site for integrating miniaturised EEG electrodes and sensors, but its compliant, …
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Model-based Approach for Product Requirement Representation and Generation in Product Lifecycle Management
… the current Product Life-cycle Management (PLM) platforms in terms of product requirement representation and generation. After a systematic study on the categorization of product requirements, an ontological framework is developed for the specification of the requirements and related product …
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Computational Analysis of Turbulent Flow Around NACA 4412 Airfoil with Open Source CFD Software
Computational Fluid Dynamics (CFD) is a tool utilized in industry and academia to help provide a better understanding of a flow field. It is advantageous to use because building experiments for all different flow scenarios can become extremely expensive. Also, there is no need to disturb or add …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… To address these challenges, we first created a computational platform, Transite, that systematically infers RBPs influencing gene expression through changes in RNA stability. As a proof of principle, we applied Transite to RNA expression data from cancer patients with naïve or chemoresistant …
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