Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface

Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte peaks obtained through DESI by improving the temperature uniformity throughout the capillary flow. Multi-channel capillaries were discovered to be more sensitive to temperature and less prone to turbulence under certain conditions when compared to single channel capillaries. A multiple regression analysis reveals the significance of the surface-area-to-volume ratio, inlet-to-outlet area ratio, and the interaction of these main effects with temperature. This study illustrates the complex tradeoff between desolvation and ion loss, thereby providing a general guideline to instrumentation design for the purpose of maximizing signal intensity of the MS.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2021

Author dc:creator

• Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• David E. Hardt.

• Mechanical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130722

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130722