{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/130722"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/130722","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface","abstract":"Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte peaks obtained through DESI by improving the temperature uniformity throughout the capillary flow. Multi-channel capillaries were discovered to be more sensitive to temperature and less prone to turbulence under certain conditions when compared to single channel capillaries. A multiple regression analysis reveals the significance of the surface-area-to-volume ratio, inlet-to-outlet area ratio, and the interaction of these main effects with temperature. This study illustrates the complex tradeoff between desolvation and ion loss, thereby providing a general guideline to instrumentation design for the purpose of maximizing signal intensity of the MS.","abstract_html":"Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte peaks obtained through DESI by improving the temperature uniformity throughout the capillary flow. Multi-channel capillaries were discovered to be more sensitive to temperature and less prone to turbulence under certain conditions when compared to single channel capillaries. A multiple regression analysis reveals the significance of the surface-area-to-volume ratio, inlet-to-outlet area ratio, and the interaction of these main effects with temperature. This study illustrates the complex tradeoff between desolvation and ion loss, thereby providing a general guideline to instrumentation design for the purpose of maximizing signal intensity of the MS.","abstract_has_math":false,"creators":["Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology."],"institution":"Massachusetts Institute of Technology","degree_name":"Master","degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Department of Mechanical Engineering","school":null,"contributors":[],"advisors":["David E. 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