Protease activity sensors for monivasive diagnosis and monitoring of pulmonary diseases

Effective disease management requires high quality and accurate information about disease state. As science and technology have evolved, the history and physical exam, once the foundations of the diagnostic workflow, have been supplemented with modalities that allow physicians to peer inside the body and acquire otherwise inaccessible information. To gain maximal information about a disease, a promising approach would be to administer a probe that can detect disease activity inside the body and emit a signal to the outside world. To this end, our group has developed "activity-based nanosensors", which detect dysregulated protease activity at the site of disease and release a reporter that can be measured in the urine. Because proteases are implicated in multiple diseases, including cancer, activity-based nanosensors have the potential to enable quantitative, noninvasive, and real-time monitoring of disease activity.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Harvard University--MIT Division of Health Sciences and Technology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Kirkpatrick, Jesse D.

Advisor dc:contributor.advisor

• Sangeeta N. Bhatia.

• Harvard--MIT Program in Health Sciences and Technology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130206

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130206