Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"multiple diseases"”.
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How does polypharmacy impact on the quality of life of older people in New Zealand?
… over the world and people are living longer with multiple diseases thanks to the development of pharmaceuticals and other health care facilities. Older people who suffer from multiple diseases require multiple medications to control the severity of the disease. Polypharmacy can lead to the …
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Chest X-Ray Image Classification with Deep Learning
… following three aspects. First, considering most diseases existing in CXRs usually happen in small, localized areas, we propose to localize the local discriminative regions and integrate the global and local cues into an attention guided convolution neural network (AG-CNN) to identify thorax …
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An evaluation of the relative importance of technical and non- technical factors which affect water and sanitation projects in developing countries
… case studies of control methods of different diseases were evaluated. This led to recommendations of appropriate mixes of technical and non-technical services for disease control. This evaluation was utilized to develop a planning approach to effectively integrate interagency efforts for the …
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Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle
… health problems in humans and animals globally. Diseases in tropical and remote areas, sometimes known as neglected tropical diseases, pose some of the greater problems due to the difficulty in collecting and analysing samples. Collecting samples from remote and tropical areas is difficult, …
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Protease activity sensors for monivasive diagnosis and monitoring of pulmonary diseases
… the urine. Because proteases are implicated in multiple diseases, including cancer, activity-based nanosensors have the potential to enable quantitative, noninvasive, and real-time monitoring of disease activity.
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in the development of clinically successful CB1R drugs. The identification of GPCR interacting proteins has provided additional insight into the fine-tuning and …
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Inhibition of <em>Escherichia coli</em> ATP Synthase Using Bioflavonoids.
… Malfunction of ATP synthase is associated with multiple disease conditions. This enzyme is not only implicated in disease conditions but also likely to contribute in new therapies for multiple diseases by being a molecular target for several inhibitors. Bioflavonoids are a class of plant …
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Advancing Explainability in Multi-Label Classification for Tomato Disease Detection Using Machine Learning Interpretability Techniques
<p>Plant diseases pose a significant threat to global food security, affecting crop yield, quality, and overall agricultural productivity. Traditionally, diagnosing plant diseases has relied on timeconsuming visual inspections by experts, which can often lead to errors. With the rapid growth of …
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Elucidating the Molecular Function of Reprolysin Metalloproteases in Tick-Host-Pathogen Interaction
… feeding. <em>A. americanum</em> is a carrier of multiple diseases, including <em>Ehrlichia chaffeensis</em>, the causative agent of Human Monocyte Ehrlichiosis. This experiment consisted of two main goals: the first was to characterize <em>A. americanum</em> Reprolysin Metalloproteases, and the …
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Genetic architecture of multiple disease resistance in one maize chromosome segment substitution line population
… plants, maize is attacked by numerous pathogens. Diseases account for 2 to 15% of maize yield losses annually, and foliar diseases are the most destructive in terms of yield. With an increasing world population, utilizing host plant resistance is an environmentally and economically friendly …
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A universal outbreak risk prediction tool
… has become more serious in the 21st century. Diseases have become more likely to spread across borders and pose a greater threat than before. In order to handle this new situation, the ability to predict the risk of pandemic outbreaks is a necessary. Existing prediction tools include machine …
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Effect of Protective Covers Against Biotic and Abiotic Disorders for Grape Production in Virginia
… grape-based products, are susceptible to various diseases, pests, and disorders. These challenges are particularly pervasive in Virginia and viticultural regions in similar climates. Thus, growers routinely use insecticides and fungicides to protect their fruits. However, frequent or excessive use …
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Engineering B Cells For Use In Immunotherapy and Cancer
… been shown to control inflammatory responses in multiple diseases through the production of anti-inflammatory cytokines, including interleukin (IL)-10, IL-35 and transforming growth factor-beta (TGF-b). Ex vivo expansion of B cells has been challenging due to their tendency to undergo apoptosis …
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Highly Constrained Kinetic Models for Quantitative Single-Cell Gene Expression Analysis
… mechanisms will help us understand multiple diseases that are caused by mis-regulation of transcription. Furthermore, a robust model that can mimic the multiple-step transcription mechanism will also help us quantitatively analyze single-cell gene expression, which is an emerging …
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Study of biological phenomena implicated in neuromuscular ageing
… (ROS) are linked to pathological denervation in multiple neurodegenerative diseases, but whether and how ROS causes denervation is unclear. Our main hypothesis was that ROS recapitulates the signalling pathways of developmental denervation to cause pathological denervation in multiple diseases. …
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Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factors
… genes with critical function and thus lead to multiple diseases. Two main repair pathways for double-strand breaks exist: homologous recombination (HR) and non-homologous end-joining (NHEJ). Whilst the regulation of HR has been heavily investigated, the regulation of NHEJ remains to be fully …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… worldwide as a result of their ability to vector multiple diseases. Mosquitocide resistance is a serious public health challenge that warrants the development of improved chemical control strategies for mosquitoes. Previous studies demonstrate the mosquito blood-brain barrier (BBB) to interfere …
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Effects of the Lr34 and Lr46 rust-resistance genes on other diseases of wheat
… genes providing durable resistance to biotrophic diseases of wheat like rusts and powdery mildew. In seedlings, these genes increased susceptibility to Septoria tritici blotch (STB), caused by Zymoseptoria tritici, in near-isogenic lines (NILs) of spring wheats Lal Bahadur (LB) and Avocet and …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… increase the risk of diabetes and cardiovascular diseases. The pathophysiological mechanisms underlying metabolic syndrome are multifaceted and one contributing factor is altered adipokines profiles. Adiponectin is the most abundant adipokine in the circulation and a low serum adiponectin level is …
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Drug Repurposing Using Gene Expression Data Mining
… a high rate of failure for multi-genic complex diseases. An alternative approach to drug discovery is to repurpose an existing drug that has been used to treat some medical conditions. Drug repurposing is considered a promising method due to its accelerated the process of drug discovery and …
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