Mapping the therapy resistance landscapes of acute leukemias using in vivo functional genomics

The recurrence of therapy resistant disease remains an intractable problem in oncology clinical care. To address this issue, investigators have traditionally focused on elucidating cell-intrinsic mechanisms that render tumors refractory to both classical chemotherapeutics and targeted agents. However, cancers resident in organs throughout the body do not develop in isolation. Instead, tumors arise in the context of the non-malignant components of a tissue, defined as the tumor microenvironement (TME). While the importance of cell-extrinsic factors in cancer biology is well established, our understanding of the TME's influence on therapeutic outcome is in its infancy. Pooled in vivo screens offer an unbiased strategy for identifying novel resistance mediators in the context of a normal immune system and microenvironment.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Ramos, Azucena.

Advisor dc:contributor.advisor

• Michael T. Hemann.

• Biology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/129040

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/129040