Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 470 for “"Cancer Biology"”.
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Understanding Nanog'S Role In Cancer Biology
<p><strong>Understanding Nanog’s Role in Cancer Biology</strong></p> <p><strong></strong>Mark Daniel Badeaux</p> <p>Supervisory Professor Dean Tang, PhD</p> <p>The cancer stem cell model holds that tumor heterogeneity and population-level immortality are driven by a subset of cells within the …
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Validation of photoacoustic imaging biomarkers in cancer biology
… a key driver of malignant disease progression in cancer, promoting higher metastatic potential, increased therapy resistance and poorer patient outcome1,2. However, the origin and impact of these hypoxic fluctuations on tumour progression have not yet been fully understood. Harnessing the …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… primary driver of oncogenic PI3K activation in cancerous, PTEN-null mouse prostate. PTEN phosphatase is a tumour-suppressor and inactivated commonly in prostate cancers. PLEKHS1 is otherwise a poorly characterised protein. This thesis presents research investigating the relevance and mechanisms …
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Insulin-like growth factor receptor activity in cancer biology & therapy responses
… essential function in normal cell growth and in cancer progression. However, anti-IGF-1R therapies have mostly been withdrawn from clinical trials owing to a lack of efficacy and predictive biomarkers. IGF-1R activity and signalling in cancer cells is regulated by its C-terminal tail, and in …
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CHARACTERIZATION OF EPCAM IN THYROID CANCER BIOLOGY BY THREE-DIMENSIONAL SPHEROIDS IN VITRO MODEL.
Thyroid cancer (TC) is the most common Endocrine malignancy. Currently, the mechanisms responsible for insensitivity to therapeutic treatments, tumor aggressiveness and tumor relapse described in undifferentiated thyroid cancers (UTCs) haven’t been fully elucidated yet. The insurgence of therapy …
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Determination of p53 role in cancer biology and therapy through interactome development and analysis
Cancer is a heterogeneous pathology of cell and tissue type, involving multi- dysregulation of pathways that govern fundamental cellular processes. Chemotherapy efficacy is highly affected by these molecular deviations and the majority of patients are non-responsive. The stress responsive …
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Development of Bioluminescent Biosensors Monitoring Activity of the Merlin Tumour Suppressor
… in CIP and is inactivated in a wide variety of cancers, suggesting that it is a tumour suppressor of general importance in cancer biology. Although the role of Merlin in cancer has been investigated extensively, this protein lacks intrinsic catalytic activity and has been notoriously difficult …
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Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma
<p>In the last twenty years both computational biology and cancer biology have made great strides and in the last 5 years the merger of the two has helped to revolutionize our knowledge of personalized targeted therapy and the diversity of cancer. In cancer, cell-to-cell interactions between tumor …
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Controlling Curvature and Stiffness in Fibrous Environments Uncovers Force-Driven Processes and Phenotypes
… focused at exploring disease progression of cancer biology through the perspective of mechanical engineering. We explore cancer through a holistic approach considering mechanistic, physical, genetic biology, biochemical, and immune cells to explore how the interplay with fiber networks can …
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Specialized Named Entity Recognition for Breast Cancer Subtyping
… example of this is the field of breast cancer biology where over 2 million people are diagnosed worldwide every year and billions of dollars are spent on research. Breast cancer biology literature and research relies on a highly specific domain with unique language and vocabulary, and …
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Regulatory roles of endothelial cells in cancer
… cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine regulatory cells. We focus on how the endothelial cells …
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Role of RNA methyltransferases in lung cancer
… because their activities are relevant to cancer biology, and they are therefore potential targets for novel therapeutic intervention. Here, I target validated two RNA methyltransferases. I performed a late-stage study of METTL3, and I initiated and developed an early-stage analysis of …
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Defining oncogenic determinants in prostate cancer initiation and progression
… analysis of primary and metastatic prostate cancer and uncovered previously uncharacterized genetic alterations in cancer genome. Functionally association the genetic abnormalities with the prostate cancer initiation and progression is necessary for a better understanding of the prostate …
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Genetic screens in vivo using the CRISPR/Cas9 system
An unmet and paramount need in the field of cancer research is to rapidly translate basic biological findings to clinically relevant therapeutics for cancer patients. Recent technological advances have generated many innovative applications to cancer biology and in a short time have yielded a …
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Mapping the therapy resistance landscapes of acute leukemias using in vivo functional genomics
… chemotherapeutics and targeted agents. However, cancers resident in organs throughout the body do not develop in isolation. Instead, tumors arise in the context of the non-malignant components of a tissue, defined as the tumor microenvironement (TME). While the importance of cell-extrinsic …
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Adhesion-GPCRs in cancer progression and metastasis
… analyses of genetic alterations across diverse cancer types have revealed significant alterations (copy number and mutational) in adhesion-GPCRs, yet no comprehensive examination of their roles in cancer biology exists. Through a systematic screening for all adhesion-GPCRs by RT-qPCR in murine …
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Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology
… that can aid in understanding the mechanism of cancer biology. Here we described the creation of synthetic tools that can be applied to study the role of a transcription factor(s) in cancer biology. Firstly, we described the creation, using recombineering technology, of universal bacterial …
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The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.
… factors that have gained prominence in cancer biology. For example, endogenous TBX2 is overexpressed in a growing list of cancers and when ectopically overexpressed it can bypass senescence and the tetraploidy checkpoints that protect against cancer. When the current study was initiated …
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Non-parametric algorithms for evaluating gene expression in cancer using DNA microarray technology
… technology has transformed the field of cancer biology by enabling the simultaneous evaluation of tens of thousands mRNA expression levels in a single experiment. This technology has been applied to medical science in order to find gene expression markers that cluster diseased and normal …
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Mining common genetic Variants impacting on Allele-Specific Translation and cancer risk
… cellular homeostasis, with deep implications for cancer biology. The work described in this thesis identifies, validates, and investigates allele-specific differences in translation efficiency mediated by tranSNPs: genetic variants that influence mRNA translation. By leveraging RNA-seq data from …
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