An organoid platform to study alveolar stem cells in lung generation and cancer

Lung adenocarcinoma (LADC) remains the most common and lethal cancer type worldwide. Although recent breakthroughs using a new class of immune-modulatory therapeutics have improved patient survival in the clinic, the majority still invariably succumb to this disease, highlighting the importance of improving treatment strategies. A wide variety of models have been developed to study LADC. Cell line- and transplant-based models offer rapid and flexible platforms for discovering and testing novel therapeutics using patient-derived specimens. On the other hand, genetically engineered mouse models (GEMMs) recapitulate key aspects of human LADC including initiation from normal pulmonary epithelial cells and progression into a malignant state. The development of organoid technology has revolutionized the way we model cancer and a vast number of other biological phenomena.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Naranjo, Santiago(Santiago Jose)

Advisor dc:contributor.advisor

• Tyler Jacks.

• Biology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/129032

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/129032